Several mental conditions and depression, have been linked to immune response disorganization. However, it is unclear if particular mediators play a part in the etiopathogenesis of depression. Although there are no definite biomarkers diagnose current study sought logically evaluate possibility feasibility checking biomarker for depression be utilized hospitalized patients suspected In this nar...

Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...

background: tnf-α is a multifunctional proinflammatory cytokine and tgf-β1 is a secretory protein controlling epithelial proliferation and differentiation. keratocyst presents an aggressive behavior and a growth mechanism different from that of radicular cyst. aim: in this line, the present study aimed at evaluating tnf-α and tgf-β1 level and its association with histopathological findings in t...

introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. male wistar rats (250-300 g) were divided into ischemia and treatment groups. after inductio...

Background: The process of wound healing involves integrated events including inflammation, granulation tissue formation, matrix deposition and remodeling. Growth factors play a key role in the process. Among them transforming growth factor-ß1 (TGF-ß1) is known to accelerate tissue repair by promoting the synthesis and deposition of extracellular matrix proteins. However, persistence or overact...

Systemic sclerosis (SSc) is a chronic autoimmune disease, featuring fibrosis in multiple organs. The serum from SSc patients contain inflammatory mediators, contributing to SSc pathogenesis and could be used to develop cell culture models. Here, we compared the fibrotic effects of serum samples from SSc patients with TGFβ1 on human dermal fibroblasts (HDFs). HDF cells were cultured in four diff...

Abstract Background and Aims The transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine, with distinct roles both in fibrosis inflammation acts through the Smad signalling renal injury. We sought expression of TGF-β1/Smad ANCA associated glomerulonephritis (AAGN) we assessed this correlation injury at diagnosis as well progression. Method evaluated immunohistochemical TGF-β1, phosphor...