Alzheimer's disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction. The Wnt signaling pathway participates in the development of the central nervous system and growing evidence indicates that Wnts also regulate the function of the adult nervous ...

The secreted Frizzled-related proteins (sFRP) are modulators of the Wnt signaling pathway, which is involved in embryonic development and tumor progression. The functions of sFRP2 have not been studied in renal cancer. Transient transfection of sFRP2 promoted cell growth in renal carcinoma cells, whereby the largest effect was observed in A498 cells. To further study the functions of sFRP2 gene...

Multiple drug resistance (MDR) is considered a major challenge in the clinical treatment of non-small cell lung cancer (NSCLC). Both nitric oxide synthase (iNOS) and Wnt signaling pathway participate in the regulation of drug resistance, but the interaction between them remains unclear. In the present study, we detected the activation of Wnt/β-catenin signaling in iNOS-induced drug-resistant lu...

BACKGROUND Secreted frizzled-related proteins (SFRP) are regulators of Wnt-signalling. SFRP4 has been shown to regulate insulin exocytosis and is overexpressed in type 2 diabetes mellitus. Here we characterized the relation of SFRP4 to glucose and triglyceride metabolism and outcomes in patients with stable coronary artery disease on statin treatment in the prospective Homburg Cream & Sugar Stu...

Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1-5) are putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as the loss of SFRP1 in many cancers, this family is generally considered to be tumour suppressive. In this study we analyzed gene expression, promoter methylation and survival data from over 8000 tumour and no...

23 24 25 Recent studies of myocardial infarction in secreted Frizzled-related protein 2 (sFRP2) 26 knockout mice and our hamster heart failure therapy based on sFRP2 blockade have 27 established sFRP2 as a key profibrotic cytokine in the heart. The failing hamster heart is marked 28 by prominent fibrosis and calcification with elevated expression of sFRP2. Noting the 29 involvement of tissue-no...

22 23 24 Progressive fibrosis is a pathological hallmark of many chronic diseases responsible for 25 organ failure. Although there is currently no therapy on the market that specifically targets 26 fibrosis, the dynamic fibrogenic process is known to be regulated by multiple soluble mediators 27 that may be therapeutically intervened. The failing hamster heart exhibits marked fibrosis and 28 in...

The secreted frizzled-related protein (sFRP) family plays an important role in the inhibition of the Wnt signaling pathway in various cancers. The functional significance of Wnt antagonist sFRP3 has not been investigated in renal cancer. We performed tissue microarray and found that the level of sFRP3 protein was high in normal kidney, low in primary renal cancer tissues, and high in metastatic...

Following the invitation from IRPA to comment on the article written by Professor Roger Clarke entitled 'Control of low-level radiation exposure: time for a change?', the Board of the French Society for Radiation Protection (SFRP) decided to set up a working group on 'controllable dose'. The latter, which worked from April 1999 to July 2000, consisted of some 20 members representing the stakeho...