نتایج جستجو برای: ژن kiss1

تعداد نتایج: 16558  

Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing hormone (GnRH) system in the hypothalamus of male rats. Also, we assessed the expression of two excitatory (kisspeptin and...

Journal: :Neuroendocrinology 2015
Dominique H Eghlidi Henryk F Urbanski

BACKGROUND The hypothalamus plays a key role in mediating the effects of estrogen on many physiological functions, including reproduction, metabolism, and thermoregulation. We have previously observed marked estrogen-dependent gene expression changes within the hypothalamus of rhesus macaques during aging, especially in the KNDy neurons of the arcuate-median eminence (ARC-ME) that produce kissp...

Journal: :The Journal of endocrinology 2015
F Wahab M Shahab R Behr

Recently, kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH), two counteracting neuropeptides, have been acknowledged as significant regulators of reproductive function. KP stimulates reproduction while GnIH inhibits it. These two neuropeptides seem to be pivotal for the modulation of reproductive activity in response to internal and external cues. It is well-documented that the current...

2009
A M I Knox X F Li J S Kinsey-Jones E S Wilkinson X Q Wu YS Cheng S R Milligan S L Lightman K T O'Byrne

Immunological challenge experienced in early life can have long-term programming effects on the hypothalamic-pituitary-adrenal axis that permanently influence the stress response. Similarly, neonatal exposure to immunological stress enhances stress-induced suppression of the hypothalamic-pituitary gonadal (HPG) axis in adulthood, but may also affect earlier development, including the timing of ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Nicolas de Roux Emmanuelle Genin Jean-Claude Carel Fumihiko Matsuda Jean-Louis Chaussain Edwin Milgrom

Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropi...

2013
Renjitha Gopurappilly Satoshi Ogawa Ishwar S. Parhar

Guanine nucleotide binding protein (G-protein)-coupled receptors (GPCRs) are eukaryotic transmembrane proteins found in all living organisms. Their versatility and roles in several physiological processes make them the single largest family of drug targets. Comparative genomic studies using various model organisms have provided useful information about target receptors. The similarity of the ge...

Journal: :Current Biology 2014
Cristina Sáenz de Miera Stefanie Monecke Julien Bartzen-Sprauer Marie-Pierre Laran-Chich Paul Pévet David G. Hazlerigg Valérie Simonneaux

Animals living in temperate zones anticipate seasonal environmental changes to adapt their biological functions, especially reproduction and metabolism. Two main physiological mechanisms have evolved for this adaptation: intrinsic long-term timing mechanisms with an oscillating period of approximately 1 year, driven by a circannual clock [1], and synchronization of biological rhythms to the sid...

Journal: :General and comparative endocrinology 2008
Carlos C Martinez-Chavez Matteo Minghetti Herve Migaud

The Kiss1/GPR54 system has recently been shown to play a key role in the onset of puberty in mammals. Growing evidence suggests that this system is also conserved across vertebrates although very few studies so far have been performed in lower vertebrates. The aims of this study were firstly in the teleost Nile tilapia to screen tissues for GPR54 expression levels, secondly to measure the expre...

Journal: :Frontiers in bioscience 2011
Victor M Navarro Manuel Tena-Sempere

Reproductive function, as essential for the survival of species, is under the control of a vast array of regulatory factors that ultimately modulate the release of GnRH. However, GnRH neurons lack the ability to directly sense most of these signals; hence, intermediate pathways are required. Kisspeptins have recently emerged as a pivotal piece in the reproductive brain, serving primarily as con...

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