Hepatitis B virus (HBV) infection continues to be a major health problem worldwide. The large-scale immunization programs for persons in high-risk groups, newborns, and adolescents have greatly reduced the incidence of new infection, but the ∼400 million HBV carriers with HBV surface antigen (HBsAg) in the blood remain a burden that will dwindle only within decades. Furthermore, an unknown dise...

UNLABELLED BACKGROUND Hepatitis B virus (HBV) is a common cause of viral hepatitis with significant health complications including cirrhosis and hepatocellular carcinoma. Assays for hepatitis B surface antigen (HBsAg) are the most frequently used tests to detect HBV infection. Vaccination for HBV can produce transiently detectable levels of HBsAg in patients. However, the time course and dur...

BACKGROUND The underlying mechanism of HBsAg-negative hepatitis B virus (HBV) infection is notoriously difficult to elucidate because of the extremely low DNA levels which define the condition. We used a highly efficient amplification method to overcome this obstacle and achieved our aim which was to identify specific mutations or sequence variations associated with this entity. METHODS A tot...

Hepatitis adalah penyakit peradangan pada hati yang disebabkan oleh virus, bakteri, dan parasit. tersering infeksi virus B. Prevalensi B di Indonesia sebesar 1,2 % dinyatakan sebagai negara endemik B, sehingga setiap WNI akan bepergian keluar negeri untuk menjadi tenaga kerja (TKI) wajib melakukan pemeriksaan sesuai dengan peraturan ditetapkan Departemen Ketenagakerjaan. Pemeriksaan serologi st...

BACKGROUND There are around 350 million of hepatitis B surface antigen (HBsAg) carriers worldwide, and among them, high risk of developing hepatocellular carcinoma (HCC) has been identified by epidemiological studies. To date, the molecular role of HBsAg in HCC development has not been fully studied. We have previously reported that in cell cultures, HBsAg up-regulated the expression of lymphoi...

OBJECTIVE The purpose of this study was to determine the association between PD1 expression and the clinical prognosis of diffuse large B-cell lymphoma (DLBCL) co-occurring with hepatitis B virus (HBV) infection. METHODS A total of 165 patients presented with newly diagnosed and untreated DLBCL at the First Hospital of Jilin University, Changchun, China, between 2011.01 and 2014.12. Complete ...