نتایج جستجو برای: ژن ccl2
تعداد نتایج: 19372 فیلتر نتایج به سال:
Background. Streptococcus pneumoniae is a significant cause of morbidity and mortality, especially in children. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly common and prolonged in children. Methods. We studied prolonged carriage using a mouse model of pneumococcal colonization by intranasally inoculating infant (7-day old) and adult (6-8 week old) mice...
HIV-1 envelope glycoprotein gp120 induces, independently of infection, the release of CCL2 from macrophages. In turn, this chemokine acts as an autocrine factor enhancing viral replication. In this study, we show for the first time that phosphoinositide-specific phospholipase C (PI-PLC) is required for the production of CCL2 triggered by gp120 in macrophages. Using a combination of confocal las...
ورم پستان یکی از بیماری‌های عفونی غدد پستانی در گاوهای شیری است که در چند دهه اخیر، به عنوان یکی از مهم‌ترین بیماری‌هایی که منجر به ضرر اقتصادی در صنعت گاو شیری می‌شود، مورد توجه زیادی قرار گرفته است. وراثت‌پذیری ورم پستان پایین است و لذا مدیریت اصلاح نژادی آن کار سختی به شمار می‌رود. با توجه به اهمیت بیماری ورم پستان در مدیریت واحد‌های پرورش گاو شیری و ساز و کار مولکولی پیچیده درگیر در این ب...
هدف: بررسی تاثیر پلیمورفیسم CCL2C-2518T در بیماری دژنراسیون وابسته به سن ماکولا (AMD). روش پژوهش: در این تحقیق رابطه بین پلیمورفیسمC-2518T در منطقه پروموتوری ژن CCL2 در 48 بیمار مبتلا به AMD نوع خشک از منطقه شمال‌شرق کشور (شهرستان گناباد) با استفاده از روش واکنش زنجیرهای پلیمراز (PCR) و تکنیک پلیمورفیسم، طول قطعات هضم شده (RFLP) بررسی شد. گروه شاهد از 69 فرد سالم که از نظر سن، جنس و قوم...
BACKGROUND Mucosal CXC chemokines recruit inflammatory cells to the infected urinary tract. The chemokine response repertoire of the urinary tract and the relationship to disease severity have not been examined, however. METHODS This study quantified CXC (CXCL1, CXCL3, CXCL5, CXCL8, CXCL9, and CXCL10) and CC (CCL2, CCL4, and CCL5) chemokines in sequential urine samples obtained from 50 patien...
The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell– and T-lymphocyte–dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11bþCD11cþLy6ChighLy6G MHCIIþ dendritic cell–like antigenpresenting cells (APC) into the tumor bed, but not into lymphoid organs. Accordingl...
Analogues of the mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of novel mono- and dinucleotide cap analogues containing dihalogenmethylenebisphosphonate moiety (i.e. one of the bridging O atom substituted with CCl2 or CF2) and their properties in ...
Bone marrow-derived cells (BMCs) reside in the anterior stroma of the central and paracentral cornea, as well as all stromal layers of the peripheral cornea, in normal human eyes. We investigated the factors regulating the constitutive distribution of BMCs in normal human corneal stroma. Cultured human corneal keratocytes expressed several chemokines (growth-related oncogene/CXCL1-3, IL-8/CXCL8...
Lectins are non-immunoglobulin carbohydrate-binding proteins without enzymatic activity towards the bound carbohydrates. Many lectins of e.g. plants or fungi have been suggested to act as toxins to defend the host against predators and parasites. We have previously shown that the Coprinopsis cinerea lectin 2 (CCL2), which binds to α1,3-fucosylated N-glycan cores, is toxic to Caenorhabditis eleg...
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to understand mechanisms of action of TLR6 in inflammatory responses, we investigated the effects of FSL-1, the TLR6 ligand, on expression of chemokine CCL2 and cytokine IL-1β and determined cellular factors involved in FS...
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