In the heart, Na/K-ATPase regulates intracellular Na(+) and Ca(2+) (via NCX), thereby preventing Na(+) and Ca(2+) overload and arrhythmias. Here, we test the hypothesis that nitric oxide (NO) regulates cardiac intracellular Na(+) and Ca(2+) and investigate mechanisms and physiological consequences involved. Effects of both exogenous NO (via NO-donors) and endogenously synthesized NO (via field-...

Mathematics requires thinking but also pattern recognition. Recent research indicates that perceptual learning (PL) interventions facilitate discovery of structure and recognition of patterns in mathematical domains, as assessed by tests of mathematical competence. Here we sought direct evidence that a brief perceptual learning module (PLM) produces changes in basic information extraction. Accu...

With the deregulation of the markets and the introduction of new technologies, the need to manage diversification, change and complexity in product development has become crucial. To cope with this situation an alternative foundation for PLM is needed in which organizational issues are considered alongside with more traditional technical ones. Such a major reorientation of PLM needs to be infor...

PLM tools mainly refer information systems based on a wide graph representing linked information. Such a PLM model is compatible with a metamodel often expressed in UML. UML graphics diagrams are paradigms to support sharing and understanding the concepts and relationships that must be supported by the PLM tool. Nevertheless instance diagrams contain so many objects that it is hard to present t...

Enterprise 2.0 wird in Wissenschaft und Praxis intensiv diskutiert: In zahlreichen Fallstudien wurde analysiert, wie einzelne Plattformen in unterschiedlichen Unternehmen zum Einsatz kommen. Bisher zeichnet sich in der Enterprise-2.0-Forschung noch kein Fokus auf bestimmte Branchen oder Bereiche ab. Der vorliegende Beitrag möchte einen neuen Weg gehen, indem er nicht einzelne Plattformen und de...

Conceptual design phase Is partially supported by product Iifecycie management/computer-aided design (PLM/CAD) systems causing discontinuity of the design Information flow: customer needs functional requirements key characteristics design parameters (DPs) geometric DPs. Aiming to address this Issue, It is proposed a knowledge-based approach is proposed to Integrate quality function deployment, ...

This paper studies the specific Product Lifecycle Management (PLM) capabilities needed for the transformation of Engineered to Order (ETO) manufacturing towards Configure to Order business strategy. The material for the research comes from a project conducted with public private partnership. The four industrial companies that we studied engineer and/or manufacture highly customized products in ...

To achieve different assembly operations on the aircraft structure, the aeronautic OEM needs to create and manage various fixture tools. To cope with these needs, the OEM begun to adopt the supplier integration into the tooling development process. This paper presents a conceptual PLM-based approach to support new business partnership of different suppliers. The new business partnership aims to...

Product Lifecycle Management (PLM) systems are widely used in the manufacturing industry. A core feature of such systems is providing support for versioning of product data. As workflow functionality is increasingly used in PLM systems the possibility emerges that versioning policies as encapsulated in process models are inconsistent with respect to their actual lifecycles. In this paper we def...