Cytokinesis depends on a contractile actomyosin ring in many eukaryotes [1-3]. Myosin II is a key component of the actomyosin ring, although whether it functions as a motor or as an actin cross-linker to exert its essential role is disputed [1, 4, 5]. In Schizosaccharomyces pombe, the myo2-E1 mutation affects the upper 50 kDa sub-domain of the myosin II heavy chain, and cells carrying this leth...

The human cytomegalovirus (HCMV) UL112-113 gene products play important roles in viral DNA replication and transcriptional regulation. In this report, we characterize two novel transcripts originating from the homologous M112-113 (e1) region of the murine cytomegalovirus (MCMV) genome. These transcripts of 2.0 and 2.4 kb represent alternatively spliced products of the e1 gene region. Analysis o...

Cell cycle deregulation and genomic instability play a major role in the aberrant cell proliferation that characterizes tumorigenesis. A novel role of the cyclin e isoform cyclin e2 in these processes is reported in the manuscript " Cyclin e2 induces genomic instability by mechanisms distinct from cyclin e1 " by Caldon et al. 1 in another issue of Cell Cycle, evidence that regulation of cyclin ...

A graph G is well-covered if every maximal independent set of maximum. (k,ℓ)-partition a partition its vertex into k sets and ℓ cliques. (k,ℓ)-well-covered it admits (k,ℓ)-partition. The recognition graphs polynomial-time solvable for the cases (0,1), (0,2), (1,0), (1,1), (1,2), (2,0), hard, otherwise. In sandwich problem property Π, we are given pair G1=(V,E1) G2=(V,E2) with E1⊆E2, asked wheth...

We have found that the replicative helicase E1 of bovine papillomavirus type 1 (BPV-1) interacts with a key cell cycle regulator of S phase, the cyclin E-Cdk2 kinase. The E1 helicase, which interacts with cyclin E and not with Cdk2, presents the highest affinity for catalytically active kinase complexes. In addition, E1, cyclin E, and Cdk2 expressed in Xenopus egg extracts are quantitatively co...

This is a short note inspired by some ideas and results from [3,6–8]. It is about Parsing Expression Grammars (PEGs) introduced by Ford in [1]. PEG specifies a language by defining for it a parser with limited backtracking. All of the quoted papers contain a detailed introduction to PEG, so it is not repeated here. Backtracking means that if e1 in a choice expression e1/e2 fails, the parser ret...

Let R be a commutative ring and M and N be R-modules. (We always work with rings having a multiplicative identity and modules are assumed to be unital: 1 ·m = m for all m ∈M .) The direct sum M ⊕N is an addition operation on modules. We introduce here a product operation M ⊗RN , called the tensor product. We will start off by describing what a tensor product of modules is supposed to look like....

Let G be a connected graph and g non-negative integer. A vertex set S of is called g-extra cut if G−S disconnected each component has at least g+1 vertices. The connectivity the minimum cardinality one cut. For two graphs G1=(V1,E1) G2=(V2,E2), strong product G1⊠G2 defined as follows: its V1×V2 edge {(x1,x2)(y1,y2)|x1=x2 y1y2∈E2; or y1=y2 x1x2∈E1; x1x2∈E1 y1y2∈E2}, where (x1,x2),(y1,y2)∈V1×V2. ...

Dysregulation of estrogen related pathways is implicated colorectal cancer (CRC) development. However, significance of intratissue concentration of estrone (E1) and 17β-estradiol (E2) in relation to estrogen receptor (ESR) expression level was not addressed so far. Herein, we measured E1 and E2 intratissue concentration using liquid chromatography electrospray ionization tandem mass spectrometr...