Background: Virus genome sequencing is increasingly utilized in epidemiological surveillance. Genomic data allows comprehensive evaluation of underlying viral diversity and epidemiology to inform control. For human rhinovirus (HRV), genomic amplification challenging due numerous types, high genetic inadequate reference sequences. Methods:</ns...

Similar to many flavivirus types including Dengue and yellow fever viruses, the nonstructural NS3 multifunctional protein of West Nile virus (WNV) with an N-terminal serine proteinase domain and an RNA triphosphatase, an NTPase domain, and an RNA helicase in the C-terminal domain is implicated in both polyprotein processing and RNA replication and is therefore a promising drug target. To exhibi...

Background: The maintenance, regulation, and dynamics of heterochromatin in the human malaria parasite, Plasmodium falciparum, has drawn increasing attention due to its regulatory role mutually exclusive virulence gene expression silencing key developmental regulators. The advent genome-wide analyses such as chromatin-immunoprecipitation foll...

Background: To increase vaccination coverage, it is important to understand COVID-19 programs and respondents’ acceptance. Therefore, this study aimed measure knowledge of the vaccine its acceptance among Indonesian adults in Java. Methods: A web-based survey was distributed through social media on self-claimed knowledge, risk bene...

Background: The most common severe symptoms of coronavirus disease 2019 (COVID-19) are breathing difficulty and respiratory failure. Unfortunately, mortality COVID-19 patients with difficulties is high. Clinical finding diagnosis: This report describes the case a woman in her seventies, who could not taste anything except metallic ...

Background: Children born preterm (before 37 weeks of gestation) are at risk for several adverse childhood outcomes. Parent priorities research into these outcomes, and preferences receiving information about risks, have not previously been established. Here we report the results an online survey designed to understand parent their outcomes. ...

Background: Digital interventions have the potential to reduce alcohol consumption, although evidence on effectiveness of apps is lacking. Drink Less a popular, evidence-informed app with good usability, putting it in strong position be improved upon prior conducting confirmatory evaluation. This paper describes process refining improve its u...

This study sought to determine the effect of fermented medicinal herbs (FMH), i.e. cutchery (Kaempferia galanga), turmeric (Curcuma longa) and curcuma xanthorrhiza) in combination with molasses probiotic drink (Yakult), administered orally on hematological physiological profile of...

Background: Tetanus remains common in many low- and middle-income countries (LMICs) yet the evidence base guiding management of this disease is extremely limited, particularly with respect to contemporary options. Sharing knowledge about practice may facilitate improvement outcomes elsewhere. Methods: We describe clinical intervent...

Background: There is limited data on the burden of mental disorders among ‘healthy’ children in Africa. We examined prevalence and correlates neurocognitive psychiatric schoolchildren Uganda. Methods: This cross-sectional study enrolled 322 aged 5-17years Wakiso, Uganda. assessed for impairment using Kaufmann-Assessment-Battery, (m...