Inhibition of angiogenesis by targeting the VEGF signaling pathway (VSP) has proven to be a successful anticancer strategy in a growing number of solid tumors. Although VEGF signaling is critical for tumor angiogenesis, VEGF also plays important roles in homeostasis of normal vasculature. Early trials reported the development of hypertension in a significant fraction of patients receiving antia...

RESULTS AND CONCLUSION: The challenge of craniopagus separation is due to the complexity of the venous plexus and shared dural venous sinus. Therefore, separation of the venous system of the twins requires meticulous planning and stereoscopic appreciation of the vasculature. Both VSP and 3D printed models were critical as references of the venous anatomy during separation and to the survival of...

The PRH/Hhex transcription factor represses multiple genes in the VEGF signalling pathway (VSP) to inhibit myeloid cell survival. Protein kinase CK2 phosphorylates PRH and counteracts the inhibitory effect of this protein on cell survival by blocking the repression of VSP genes. Here we show that the BCR-ABL/Src kinase inhibitor dasatinib decreases PRH phosphorylation and increases PRH-dependen...

RESULTS AND CONCLUSION: The challenge of craniopagus separation is due to the complexity of the venous plexus and shared dural venous sinus. Therefore, separation of the venous system of the twins requires meticulous planning and stereoscopic appreciation of the vasculature. Both VSP and 3D printed models were critical as references of the venous anatomy during separation and to the survival of...

Background: Craniomaxillofacial (CMF) injuries has different patterns from simple to complicated ones. Surgeons usually spend time and effort planning the optimal surgical approach avoid damage vital structures that could otherwise lead functional deficits. It is also imperative optimize skin incisions unfavourable scarring. The aim of this work assess effectiveness efficiency virtual (VSP) app...