نتایج جستجو برای: واسنجی tdr

تعداد نتایج: 3580  

Journal: :AIDS 2011
Nicaise Ndembi Raph L Hamers Kim C E Sigaloff Frederick Lyagoba Brian Magambo Bridget Nanteza Christine Watera Pontiano Kaleebu Tobias F Rinke de Wit

OBJECTIVE To assess the emergence of transmitted HIV-1 drug resistance (TDR) in Kampala, Uganda, 10 years after the scale-up of antiretroviral treatment (ART) and to compare with a previous survey among antenatal clinic attendees in 2007 (reporting 0% TDR). DESIGN A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive young adults attending two large voluntar...

Journal: :AIDS research and human retroviruses 2012
Cillian F De Gascun Allison Waters Ciara Regan Jane O'Halloran Gillian Farrell Suzie Coughlan Colm Bergin William G Powderly William W Hall

HIV-1-infected individuals with transmitted HIV drug resistance (TDR) begin antiretroviral therapy (ART) with a lower genetic barrier to resistance and a higher risk of both virological failure and of developing further resistance. TDR surveillance informs HIV-1 public health strategies and first line ART. TDR has not been studied nationally in an Irish population. This study includes all new H...

Journal: :Journal of Orthopaedic Surgery and Research 2021

Abstract Background The effectiveness of lumbar total disc replacement (TDR) with different prostheses for sagittal alignment has been reported previously. However, there are only few reports on Activ L TDR and no specific evidence regarding whether affects the clinical outcomes. Methods Eighty-seven patients who underwent mono- or bi-segmental were studied. films upright anteroposterior latera...

2018
Monica B Arruda Lídia T Boullosa Cynthia C Cardoso Carolina M da Costa Carlos Rb Alves Shirlene Ts de Lima Helena T Kaminski Agdemir W Aleixo Ana Op Esposito Ana Ms Cavalcanti Maristela Riedel José C Couto-Fernandez Selma B Ferreira Ivi Cm de Oliveira Loreci E Portal Hilda Hc Wolf Sandra B Fernandes Maria I de M C Pardini Manoel Vc Feiteiro Fernanda M Tolentino Ricardo S Diaz Giselle Isl Lopes Roberta Bl Francisco Nazle Mc Véras Ana F Pires Miriam Franchini Fábio Mesquita Amilcar Tanuri

INTRODUCTION In Brazil, more than 487,450 individuals are currently undergoing antiretroviral treatment. In order to monitor the transmission of drug-resistant strains and HIV subtype distribution in the country, this work aimed to estimate its prevalence and to characterize the nationwide pretreatment drug resistance in individuals recently diagnosed with HIV between 2013 and 2015. METHODS T...

Journal: :Spine 2016
Se-Jun Park Chong-Suh Lee Sung-Soo Chung Keun-Ho Lee Wan-Seok Kim Jun-Young Lee

STUDY DESIGN A retrospective analysis. OBJECTIVE To evaluate the long-term clinical and radiographic outcomes and to investigate who achieved the successful outcomes after lumbar total disc replacement (TDR) using ProDisc II. SUMMARY OF BACKGROUND DATA There are few evidences regarding the long-term efficacy and safety of TDR. Furthermore, it has not been addressed which patients achieved g...

2015
Andrea De Luca Maurizio Zazzi

Despite the impressive achievements of antiretroviral treatment (ART), human immunodeficiency virus type 1 (HIV-1) drug resistance remains a relevant obstacle to effective control of HIV-1 replication at both the individual and population levels. Suboptimal treatments and medication nonadherence are the major causes for selection of acquired drug resistance (ADR) in treated patients. Consequent...

Journal: :Acta orthopaedica. Supplementum 2011
Svante Berg

Low back pain consumes a large part of the community's resources dedicated to health care and sick leave. Back disorders also negatively affect the individual leading to pain suffering, decreased quality-of-life and disability. Chronic low back pain (CLBP) due to degenerative disc disease (DDD) is today often treated with fusion when conservative treatment has failed and symptoms are severe. Th...

Journal: :The Journal of antimicrobial chemotherapy 2015
Ivailo Alexiev Anupama Shankar A M J Wensing Danail Beshkov Ivaylo Elenkov Mariyana Stoycheva Daniela Nikolova Maria Nikolova William M Switzer

OBJECTIVES To determine transmitted drug resistance (TDR) and HIV-1 genetic diversity in Bulgaria. METHODS The prevalence of TDR and HIV-1 subtypes was determined in 305/1446 (21.1%) persons newly diagnosed with HIV/AIDS from 1988 to 2011. TDR mutations (TDRMs) in protease and reverse transcriptase were defined using the WHO HIV drug mutation list. Phylogenetic analysis was used to infer poly...

2015
Thomas Jahn Florian Keil

Transdisciplinarity has a long tradition – both in terms of academic discourse and research practice. The proliferation of transdisciplinary research (TDR) has, however, only progressed moderately up until now. The main reason for this is the lack of a generally accepted quality standard for TDR. In addition to meeting the quality standards of excellence of ‘normal science’, TDR is supposed to ...

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Charles Antzelevitch

This review examines the role of spatial electrical heterogeneity within the ventricular myocardium on the function of the heart in health and disease. The cellular basis for transmural dispersion of repolarization (TDR) is reviewed, and the hypothesis that amplification of spatial dispersion of repolarization underlies the development of life-threatening ventricular arrhythmias associated with...

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