Superimposed epitopes, in which a shorter epitope is embedded within a longer one, can be presented by the same HLA class I molecule. CD8(+) CTL responses against such epitopes and the contribution of this phenomenon to immune control are poorly characterized. In this study, we examined HLA-A*24:02-restricted CTLs specific for the superimposed HIV Nef epitopes RYPLTFGWCF (RF10) and RYPLTFGW (RW...

In the last talk of this conference, Joanne Walters-Wayland will discuss a continuum of minimizable properties of sublocales of a (completely regular) locale. By that is meant a property P such that above any dense sublocale S of a locale L there is a least sublocale having property P. Such properties induce a contraction of the lattice of prenuclei of the frame, i.e., an order-preserving map w...

Acknowledgements This Habilitation thesis presents my work of the last 5 years, mostly done at ETH Zurich and partly at University College London. This was a really exciting time, and I owe a great deal of gratitude to my numerous colleagues and friends. Price: For his friendship and inspiring discussions, both scientific and personal. David's style (best described as " light-hearted wisdom ") ...

Introduction Two large paediatric studies are currently underway in the U.S. to investigate efficacy and safety of MP29-02 (Dymista) in children, with a view to extending its indication to those aged ≥6 yrs. In line with FDA recommendations, these studies compare MP29-02 to placebo. To mimic the clinical trial design of these on-going pediatric studies, this meta-analysis assessed all data avai...

The immatures stages of 8 of the 11 genera (Amastris Stål, Bajulata Ball, Erosne Stål, Harmonides Kirkaldy, Idioderma Van Duzee, Neotynelia Creão-Duarte & Sakakibara, Tynelia Stål, and Vanduzea Goding) of the tribe Amastrini are described for the first time along with brief diagnoses of Membracidae and the subfamily Smiliinae. A key to genera and notes on biology are provided. Multiple species ...

مکان‌یابی با درنظرگرفتن موضوع رقابت در بازار، یک تصمیم راهبردی و بلندمدت محسوب می­‌شود. چنانچه انتخاب مکان، بررسی‌­های لازم صورت نگیرد، حیات سازمان تحت تأثیر قرار می‌­گیرد. به‌­دلیل وجود پیچیدگی‌­های موجود مسائل مکان‌یابی، ارائه مدل‌های محدودیت­‌های متنوعی مواجه است. هدف این پژوهش، توسعه مدل رقابتی درنظر­گرفتن دو محصول از سوی سه رقیب است؛ برای منظور، مسئله به‌­صورت بازی مکان ـ قیمت تعریف استفاد...

Background GSK is investigating an autologous TCR T-cell therapy for solid tumors that recognizes the cancer testis antigen, NY-ESO-1, presented on cell surface by specific HLA-A*02 sub-types. The aim of this study was to estimate number patients in US 2020 with genotype subtypes HLA-A*02:01, 02:05, 02:06 across selected types (invasive lung, ovarian, gastric, esophageal, invasive and in-situ b...

P mparison with Brazilian populations. The genotypes RHCE*Ee, K ore prevalent in the population from the state of Santa Catarina i *Cc, RHCE*cc, RHCE*ee, FY*01/FY*02, FY*01/FY*02.N01, FY*02/FY*02, F ypes were more common in the population from the state of S erved in the comparison with Brazilian populations. The genot JK*02/02 were more prevalent in the population from the state of S ddition, ...