Bewick, N. L., C. Fernandes, A. D. Pitt, H. H. Rasmussen, and D. W. Whalley. Mechanisms of Na1-K1 pump regulation in cardiac myocytes during hyposmolar swelling. Am. J. Physiol. 276 (Cell Physiol. 45): C1091–C1099, 1999.—We have previously demonstrated that the sarcolemmal Na1-K1 pump current (Ip) in cardiac myocytes is stimulated by cell swelling induced by exposure to hyposmolar solutions. Ho...

Braam, Branko. Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1551–R1561, 1999.—If, only 20 years ago, anyone had postulated that the absence of nitric oxide gas (NO) would lead to severe hypertension and destruction of the vascular bed of the kidney within weeks, it is not un...

Kriston, Tünde, Rocco C. Venuto, Christine Baylis, and György Losonczy. Hemodynamic and renal effects of U-46619, a TXA2/PGH2 analog, in late-pregnant rats. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R831–R837, 1999.—The vasoconstrictor effects of pressor agents are attenuated during pregnancy. Thromboxane A2 (TXA2) is produced in great quantities during hypertension in pre...

ROSLYN M. LONDON,2 SAMMY L. EBER,1,2 SANDHYA S. VISWESWARIAH,4 WILLIAM J. KRAUSE,3 AND LEONARD R. FORTE1,2 1Harry S. Truman Memorial Veterans Hospital and Departments of 2Pharmacology, and 3Pathology and Anatomical Sciences, School of Medicine, Missouri University, Columbia, Missouri 65212; and 4Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalo...

Huang, Qin-Heng, Victor J. Hruby, and Jeffrey B. Tatro. Role of central melanocortins in endotoxin-induced anorexia. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R864–R871, 1999.—Inflammation and microbial infection produce symptoms, including fever, anorexia, and hypoactivity, that are thought to be mediated by endogenous proinflammatory cytokines. Melanocortins are known to...

Stricklett, Peter K., Raoul D. Nelson, and Donald E. Kohan. The Cre/loxP system and gene targeting in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F651–F657, 1999.—The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby ...

Ikezaki, Hiroyuki, Manisha Patel, Hayat Önyüksel, Syed R. Akhter, Xiao-pei Gao, and Israel Rubinstein. Exogenous calmodulin potentiates vasodilation elicited by phospholipid-associated VIP in vivo. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1359–R1365, 1999.—The purpose of this study was to determine whether exogenous calmodulin potentiates vasoactive intestinal peptide (V...

Tian, Jean Q., and Andrea Quaroni. Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation. Am. J. Physiol. 276 (Cell Physiol. 45): C1245– C1258, 1999.—Using the conditionally immortalized human cell line tsFHI, we have investigated the role of cyclindependent kinase inhibitors (CKIs) in intestinal epithelial cell differentiation. Expression of cyclins, cyclin-...

Dobrian, Anca, Suzanne S. Wade, and Russell L. Prewitt. PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H2159–H2167, 1999.—We previously demonstrated remodeling of large and small arteries in angiotensin II-treated rats, paralleled by an increased expression of platelet-derived growth factor (PDGF)...

Meng, Xianzhong, Brian D. Shames, Edward J. Pulido, Daniel R. Meldrum, Lihua Ao, Kyung S. Joo, Alden H. Harken, and Anirban Banerjee. Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1525–R1533, 1999.—This study tested the hypothesis that in vivo norepinephrine (NE) treatme...