The purpose of this clinical trial was to evaluate the utility of boron neutron capture therapy (BNCT) using epithermal neutrons for cases of recurrent cancer in the oral cavity, which are not indicated for a conventional treatment modality. We enrolled four patients with local recurrence or metastasis to the regional lymph nodes after completion of initial treatments, including surgery, chemot...

Boron Neutron Capture Therapy (BNCT) is known to be a promising and new cancer therapy which can kill tumor cells suppressing damage to normal tissues. Recently, accelerator based neutron sources (ABNS) for BNCT are under development especially in Japan. For characterization of the neutron field, we carried out the series study concerning thermal/epi-thermal neutron spectrometry especially for ...

Radiation therapy is the therapeutic modality in which high energy radiations are used to kill tumor cells [1]. Conventional radiation therapy is a whole body radiation process resulting in numerous side effects, highlighting the need to identify alternative targeted therapy [1]. BNCT is a targeted therapy in which cancer cells accumulate boron and are subsequently bombarded with neutrons [2]. ...

Background: Boron neutron capture therapy (BNCT) is a binary radiotherapy combining biochemical targeting with neutron irradiation. However, monitoring the boron distribution is a fundamental problem in BNCT. Prompt gamma rays emitted by boron capture reaction can be used to address the issue. Materials and Methods: The general-purpose Monte Carlo toolkits Geant4 and MCNP were used for the simu...

brain tumors. Shortly thereafter, a clinical trial was initiated at the Brookhaven National Laboratory in cooperation with Sweet and others at the Massachusetts General Hospital utilizing borax as the capture agent (5, 6). The objective at that time was to use BNCT as an adjunct to surgery for the treatment of patients with the most highly malignant and therapeutically refractory of all brain t...

A number of boron neutron capture therapy (BNCT) clinical trials are currently underway around the world. Due to the small number of patients at each of the individual centers, it is desirable to pool the clinical data from each into one patient database. Before this can be done, a number of differences between the clinical centers must be evaluated. The patients treated at the BNCT centers at ...

Boron Neutron Capture Therapy (BNCT) [4, 5] is a form of a radiation therapy used for treatment of some kinds of cancer (mainly glioblastoma multiforme) which, due to their character, are hard to be extracted with surgical methods. The BNCT method involves the delivery of a capture compound − the B isotope is usually used – which preferentially concentrates in the cancer tissue, followed by the...

BACKGROUND Real-time measurement of thermal neutrons in the tumor region is essential for proper evaluation of the absorbed dose in boron neutron capture therapy (BNCT) treatment. The gold wire activation method has been routinely used to measure the neutron flux distribution in BNCT irradiation, but a real-time measurement using gold wire is not possible. To overcome this issue, the scintillat...