Systematically distinguishing genetic liability from other contributing factors is critical for designing a preventive strategy for post-traumatic stress disorder (PTSD). To address this issue, we investigated a murine model exposing C57BL/6j, DBA/2j and BALB/cj mice to repeated stress via exposure to conspecific aggressors (Agg-E). Naïve mice from each strain were subjected to the proximity of...

One of today’s most frequently discussed topics in the business world is how to escape from the intense Red Ocean and how to create an uncontested Blue Ocean. However, because there are few practical guidelines available on this topic, we will introduce a case study of a third-party logistics (3PL) provider, CJ-Global Logistics Service (CJ-GLS), to show how it aspires to be a leader in the newl...

Serial coronal or sagittal sections were stained for myelin and examined in 6 inbred, 4 hybrid, and 2 outbred mouse strains. Absent corpus callosum was seen only in BALB/cJ as reported by Wimer, but a wide range of the size of corpus callosum was also noted. The action of a major gene was not evident in backcross or F2 generations; polygenic and perhaps epistatic inheritance was indicated. In A...

Purpose Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes. Methods GTM3, primary human GTM 125-05, and cultured mouse TM cells were trans...

A central political and decision science issue is to understand how election outcomes can change with the choice of a procedure or the slate of candidates. These questions are answered for the important Copeland method (CM) where, with a geometric approach, we characterize all relationships among the rankings of positional voting methods and the CM. Then, we characterize all ways CM rankings ca...

Importance sampling has been reported to produce algorithms with excellent empirical performance in counting problems. However, the theoretical support for its efficiency in these applications has been very limited. In this paper, we propose a methodology that can be used to design efficient importance sampling algorithms for counting and test their efficiency rigorously. We apply our technique...

The structure of a two-phase steady detonation in a granulated solid propellant is studied, and existence conditions for a one-dimensional, steady two-phase detonation are given. Ordinary differential equations from continuum mixture theory are solved numerically to determine steady wave structure. In the limiting case where heat transfer and compaction effects are negligible, the model reduces...

Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure. We have identified and characterized a mitochondrial membrane protein in yeast, Fcj1 (formation of CJ protein 1), which is specifically enriched in CJs. Cells lacking Fcj1 lack CJs, exhibit concentric stacks of inner membrane in the mitochondr...

Service composition in Service Oriented Computing concerns not only integration of heterogeneous distributed applications but also dynamic selection of services. Quality of Service (QoS) plays a key role in service composition as services providing the same functionalities can be differentiated according to their QoS guarantees. At subscription time, a service requester and a provider may sign ...