Mechanical coupling between a cell and substrate relies on focal adhesions, clusters of adhesion proteins linking stress fibers (bundles of actin proteins) inside the cell with surrounding tissue. Focal adhesions have been demonstrated to both measure and regulate the mechanical traction along the stress fibers. We present a quantitative model for focal adhesion mechano-sensing and stress regul...

We consider the problem of Euclidean reconstruction from two perspective images. This problem is well studied for calibrated cameras, and good algorithms are known. On the other hand, if the cameras are known to have square pixels (no skew and unit aspect ratio) then the problem is also theoretically solvable, provided an estimate of the principal point is provided. The focal lengths of the cam...

As developing or regenerating neurons grow, their axons seek cues in the extracellular matrix that are recognized by integrin receptors. To understand the regulation and structure of neural integrin complexes, we have examined the association of two functionally important integrins, alpha 1 beta 1 and alpha 3 beta 1, within PC12 cells. Detergent-resistant cytoskeletal ghosts were prepared from ...

The Nuremberg judgement famously held that crimes against international law are committed by men, not abstract entities – but who, then, is to prevent these crimes? In 2005, all UN Member States agreed it was their responsibility protect populations atrocity (short R2P). 2010, the idea born appoint senior government officials act as individual R2P Focal Points help implement this historic pledg...

1. Objectives: To synthesize research that has used a focal species approach to conserve biodiversity in managed landscapes. In particular the objectives were: a) Summarize and evaluate research that has used the focal species approach and construct criteria for using this approach. SFMN research will be highlighted, but a broader synthesis will be undertaken. b) Critique the use of focal or in...