AIM To investigate the real-world efficacy and safety of sofosbuvir/ribavirin (SOF/RBV) therapy for Japanese patients with genotype 2 hepatitis C virus (GT2-HCV). METHODS A total of 182 patients with GT2-HCV infection who received SOF/RBV therapy for 12 wk at our hospital were enrolled. The patients comprised 122 men and 60 women (age range: 17-84 years; mean age ± SD: 60.1 ± 12.1 years). Relat...

conclusions according to the results, total direct medical costs for hcv patients in iran exceeded 12 billion ppp$ in (inf-rbv) treatment and 55 billion ppp$ in (peg-rbv). results average direct medical costs for the courses treated with conventional interferon plus ribavirin (inf-rbv) were 4,403 ppp$, and 20,010 ppp$ for peg-interferon plus ribavirin (peg-rbv) courses. there was an increase of...

This paper studies platform ecosystems, a novel business entity built upon a platform coordinating the interactions between suppliers and users, particularly in the IT service sectors. Borrowing words from two core firm theories resource-based view (RBV) and transaction cost view (TCV), we propose that the platform ecosystem works at the boundary between “market and hierarchy.” To show this, ...

background most thalassemic patients with chronic hepatitis c virus (hcv) infection do not respond to therapy with pegylated interferon (peg-ifn) plus ribavirin (rbv) due to hepatic siderosis and rbv dose reduction caused by rbv-induced anemia. objectives in the present study, we recruited hcv genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with peg-ifn plus ...

Background An estimated 170 million individuals worldwide are infected with the hepatitis C virus (HCV). Although treatment options using a combination of pegylated interferon and ribavirin (P-IFN/RBV) are available, sustained clearance of the virus is only achieved in approximately 40% of individuals infected with HCV genotype 1. Recent advances in the treatment of HCV using directly acting an...

BACKGROUND Assessment of volume state is difficult in hemodialysis patients. Whether continuous blood volume monitoring can improve the assessment of volume state is unclear. STUDY DESIGN Diagnostic test study. SETTINGS & PARTICIPANTS Asymptomatic long-term hemodialysis patients (n = 150) in 4 university-affiliated hemodialysis units. INDEX TESTS Ultrafiltration rate (UFR) divided by post...

TO THE EDITOR—Patients with hepatitis C virus (HCV) genotype 1 infection should receive 12 weeks of triple combination therapy with the first-generation HCV protease inhibitor telaprevir, pegylated interferon (peg-IFN) alfa-2a or alfa-2b, and ribavirin (RBV), followed by 12 or 36 weeks of double therapy with pegIFN and RBV [1]. We report a case of sustained virologic response (SVR) achieved aft...

The resource-based view of the firm (RBV) has become the dominant framework in strategic management research. Its basic assumption is that firms can exploit strategic assets in order to create competitive advantage and thus above average performance. Another core assumption of the RBV is that strategic assets can be complementary. This means their value increases when they are combined. “Comple...