The anticancer drug irinotecan (CPT-11) is activated to the potent topoisomerase I inhibitor, SN-38 (7-ethyl-10-hydroxycamptothecin), by esterases. SN-38 is in turn conjugated to the inactive SN-38 glucuronide (SN-38G). The reverse reaction is mediated by beta-glucuronidases. Hence, production of SN-38 may occur through either pathway. In this study we conducted in vitro studies to examine thes...

kalateh ahani is located 27 km southeast of gonabad within the khorasan razavi province. the area is part of lut block. sub-volcanic monzonitic rocks intruded regional metamorphosed shemshak formation (jurassic age). magnetic susceptibility of less altered monzonitic rocks is 0.6%., as, pb and zn > 1%, au up to 150 ppb and sn = 133 ppm. the sn content of vein in the northern part of kalateh aha...

We study in detail the algebra Sn in the title which is an algebra obtained from a polynomial algebra Pn in n variables by adding commuting, left (but not two-sided) inverses of the canonical generators of Pn. The algebra Sn is non-commutative and neither left nor right Noetherian but the set of its ideals satisfies the a.c.c., and the ideals commute. It is proved that the classical Krull dimen...

We are interested in examples of compact, complete, locally CAT(-1) spaces X, and closed totally geodesic codimension two subspaces Y , with the property that ∂∞X̃ = Sn+2 ∞ , and ∂ ∞Ỹ = Sn ∞. We show that if the inclusion S n ∞ ↪→ Sn+2 ∞ induced by the inclusion Y ⊂ X is knotted, then it is a totally wild knot (i.e. nowhere tame). We give examples where the inclusion Sn ∞ ↪→ Sn+2 ∞ is indeed kno...

We present photometric and spectroscopic observations of the Type Ib supernova (SN Ib) 1996N in NGC 1398. The supernova has been observed at several occasions between 179 and 337 days after discovery. The light curves in V , R and I have decline rates of 1.67±0.23, 1.72±0.10 and 1.93±0.24 mag (100d)−1 respectively, substantially faster than the decay rate of 56Co. The late light curves of SN 19...

The present study has investigated the effect of panipenem, a widely used antibiotic, on the pharmacokinetics of an active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxy-camptothecin (SN-38) and SN-38 glucuronide (SN-38G) produced by uridine-diphosphate glucuronosyltransferase (UGT) 1A isoform-mediated glucuronidation in rats. Rats received a 1 h infusion with panipenem at a loading dose...

We present extensive photometric and spectroscopic observations of the Type Ia supernova (SN Ia) 2000cx in the S0 galaxy NGC 524, which reveal it to be peculiar. Photometrically, SN 2000cx is different from all known SNe Ia, and its light curves cannot be fit well by the fitting techniques currently available. There is an apparent asymmetry in the B-band peak, in which the premaximum brightenin...

We present a study of the effects of clumping on the emergent spectral energy distribution (SED) from dusty supernova (SN) shells illuminated by a diffuse radiation source distributed throughout the medium. These models are appropriate for Type II SNe older than a few hundred days, when the energy input is dominated by γ-rays from Co decay. The fully 3D radiation transport problem is solved usi...

We present spectroscopy and photometry of the He-rich supernova (SN) 2008ax. The earlytime spectra show prominent P-Cygni H lines, which decrease with time and disappear completely about 2 months after the explosion. In the same period He I lines become the most prominent spectral features. SN 2008ax displays the ordinary spectral evolution of a Type IIb supernova. A stringent pre-discovery lim...