OBJECTIVE The aim of this study was to develop and validate a scoring system for bowel dysfunction after low anterior resection (LAR) for rectal cancer, on the basis of symptoms and impact on quality of life (QoL). BACKGROUND LAR for rectal cancer often results in severe bowel dysfunction (LAR syndrome [LARS]) with incontinence, urgency, and frequent bowel movements. Several studies have inve...

Abstract Identifying the future threats to crop yields from climate change is vital underpin continuous production increases needed for global food security. In present study, vulnerability of European wheat yield heat and drought stresses around flowering under was assessed by estimating 95-percentiles two indices at rain-fed conditions: stress index (HSI95) (DSI95). These represent relative l...

The Whole of Government (WG) approach is increasingly seen as an imperative for delivering coherent and integrated policies, joined up and seamless services, and integrated program management in government. Although no generic WG framework currently exists, there are reported cases of WG initiatives by different governments. Grounded in existing theories, frameworks and cases related to inter-o...

BACKGROUND Secreted signaling proteins of the Wingless (Wg)/Wnt, Hedgehog and bone morphogenetic protein (BMP)/Decapentaplegic (Dpp) families function as morphogens to control growth and pattern formation during development. Although these proteins have been shown to act directly on distant cells in the developing limbs of the fruit fly Drosophila, little is known about how ligand gradients for...

The impacts of future climate changes on watershed hydrochemical processes were assessed based the newest Shared Socioeconomic Pathways (SSP) scenarios in Coupled Model Intercomparison Project Phase 6 (CMIP6) Tianhe River middle area China. monthly spatial downscaled outputs General Circulation Models (GCMs) used, and a new Python procedure was developed to batch pick up site-scale change infor...