نتایج جستجو برای: میکرودایلوشن mic
تعداد نتایج: 16071 فیلتر نتایج به سال:
In vivo studies have described the pharmacodynamic (PD) characteristics of several triazoles. These investigations have demonstrated that the 24-h area under the concentration-time curve (AUC)/MIC ratio is the critical pharmacokinetic (PK)-PD parameter associated with treatment efficacy. Further analyses from these in vivo studies have demonstrated that a triazole free drug 24-h AUC/MIC of 20 t...
The pharmacokinetics of ciprofloxacin and sparfloxacin were simulated in vitro and the effects of pharmacodynamic parameters on bactericidal activity and the emergence of quinolone resistance were examined for Streptococcus pneumoniae. Simulated serum concentrations of ciprofloxacin 500 mg bd were more rapidly bactericidal than sparfloxacin 200 mg bd, despite lower values for the key pharmacody...
BACKGROUND Staphylococcus aureus endocarditis has a high mortality rate. Vancomycin minimum inhibitory concentration (MIC) has been shown to affect the outcome of methicillin-resistant S. aureus bacteremia, and recent data point to a similar effect on methicillin-susceptible S. aureus bacteremia. We aimed to evaluate the effect of vancomycin MIC on left-sided S. aureus infective endocarditis (I...
The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1(-/-)) weighed more and had...
Ceftazidime-avibactam is a broad-spectrum-β-lactamase inhibitor combination in late-stage clinical development for the treatment of serious infections. In preparation for clinical microbiology laboratory use, a validation experiment was initiated to evaluate a commercial broth microdilution product (Sensititre dried MIC susceptibility system) compared to reference panels using 525 recent clinic...
اسانس سه گیاه دارویی شامل زنیان (Carum copticum (L.) C. B. Clarke)، زیره پارسی (Bunium persicum (Boiss.) B. Fedtsch.) و زیره سبز (Cuminum cyminum L.) به روش تقطیر با آب استخراج شد. اسانس‌های بدست آمده با استفاده از دستگاه گاز کروماتوگراف (GC) و گاز کروماتوگراف متصل به طیف‌سنج جرمی (GC/MS) تجزیه شدند و ترکیب‌های تشکیل‌دهنده آنها براساس شاخص بازداری و طیف جرمی تعیین گردید. سپس با استفاده از تکنیک...
با توجه به مقاومت باکتری ها نسبت به آنتی بیوتیک ها و نیاز روزافزون انسان به استفاده از گیاهان دارویی برای کنترل بیماری¬ها بررسی¬های بیشتر گیاهان مورد توجه محققین قرار گرفتند. لذا هدف از این تحقیق بررسی اثر ضد میکروبی عصاره تام و فراکسیون¬های کلروفرمی اتیل استاتی متانولی و آبی حاصل از بخش هوایی گیاه مریم گلی مصری علیه 5 سوش باکتریایی و یک سوش قارچی بود. گیاه salvia aegyptiaca از گیاهان اندمیک ...
Macrophage inhibitory cytokine 1 (MIC-1), a divergent member of the transforming growth factor-beta superfamily, is linked to the pathogenesis of cancer. To delineate possible roles for MIC-1 in prostate cancer, a number of prostate epithelial cell lines have been studied, including PZ-HPV-7, DU-145, PC-3, and LNCaP cells. Factors regulating the production of MIC-1 protein by these cells and so...
Rhodotorula species are emerging pathogens in immunocompromised patients. We report the in vitro activities of eight antifungals against 64 Rhodotorula isolates collected in surveillance programs between 1987 and 2003. Rhodotorula strains are resistant in vitro to fluconazole (MIC at which 50% of the isolates tested are inhibited [MIC(50)], >128 microg/ml) and caspofungin (MIC(50), >8 microg/ml...
Once-daily administration of aminoglycosides is routinely used in many institutions. However, comparative efficacy data for patients with cystic fibrosis (CF) are lacking. The purpose of the present study was to compare the predicted pharmacodynamic activity of tobramycin at 10 mg/kg of body weight/day administered every 24 h (q24h), q12h, and q8h. Pharmacokinetic (PK) data were derived from an...
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