Mirasç?l?ktan ç?karma, mirasb?rakana sakl? payl? mirasç?s?n? pay?ndan tamamen veya k?smen mahrum etme imkân? veren ölüme ba?l? tasarruftur. Türk/?sviçre Hukuk sistemlerinde mirasç?l?ktan ç?karman?n iki türü bulunmaktad?r ki bunlardan ilki koruyucu ikincisi ise cezai ç?karmad?r. Aile hukukundan do?an yükümlülüklerin önemli ölçüde ihlal edilmesi nedeniyle ç?kar?lma için birtak?m ?artlar?n gerçekl...

Kainate receptor (KAR) subunits are believed to be involved in abnormal GABAergic neurotransmission in the hippocampus (HIPP) in schizophrenia (SZ) and bipolar disorder. Postmortem studies have shown changes in the expression of the GluR5/6 subunits of KARs in the stratum oriens (SO) of sectors CA2/3, where the basolateral amygdala (BLA) sends a robust projection. Previous work using a rat mode...

Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures. Research concerning this issue has focused mainly on the hippocampus. However, several studies point to a potential role of other parts of the hippocampal formation, in particular the ...

When native and recombinant kainate receptors (KARs) are compared, there is a mismatch in several of their functional properties. While both generate currents, synaptic responses mediated by KARs have rarely observed in cultured hippocampal neurons. The recent discovery of auxiliary proteins for KARs, such as Netos, offers an explanation for these discrepancies. We found that the GluK5 KAR subu...

The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not been fully characterized. Small ubiquitin-like modifier (SUMO) modification of the KAR subunit GluK2 mediates agonist-evoked internalization, but how KAR activation leads to Glu...

Heteromeric kainate receptors (KARs) containing both glutamate receptor 6 (GluR6) and KA2 subunits are involved in KAR-mediated EPSCs at mossy fiber synapses in CA3 pyramidal cells. We report that endogenous glutamate, by activating KARs, reversibly inhibits the slow Ca2+-activated K+ current I(sAHP) and increases neuronal excitability through a G-protein-coupled mechanism. Using KAR knockout m...

In the present study, the Tangrah region located in the vicinity of GolestanNational Park was selected for exploring the changes in the amount of the secondaryessential of hypericin in Hypericum perforatum in different highlands of the easternGolestan province. The aerial flowered parts of the herb were collected randomly and inthree replications from four altitudes of 300 m, 600 m, 900 m, and ...

Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the pl...

Amaç: Çal??mam?zda alkol/madde kullan?m bozuklu?u (AMKB) tan?l? hastalarda baz? laboratuvar parametrelerini hem birbirleri aras?nda de sa?l?kl? kontrol grubu ile kar??la?t?rarak incelemeyi amaçlad?k.
 
 Materyal ve Metot: Çal??maya 25 Aral?k Gaziantep Devlet Hastanesi AMATEM (Alkol Madde Ba??ml?l??? Tedavi Merkezi) servisinde yatarak tedavi gören DSM-5 kriterlerine göre opioid, metamf...