The purpose of the present study was to investigate the suitability of bioabsorbable drawn selfreinforced polyglycolide (SR-PGA) and poly-L/DL-lactide 70:30 (SR-PLA70) implants in experimental and clinical fixations of cancellous bone osteotomies, arthrodeses and fractures. The study consists of a set of two experimental and two clinical studies, including 109 experimental animals and 87 patien...

The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates. To investigate the evolution of estrogen-binding to steroid receptors, we constructed a 3D model of amphioxus SR complexed with estradiol. This 3D model indi...

Contraction in skeletal muscle is initiated when Ca stored in the SR is released into the myoplasm in response to membrane depolarization. Studies of the mechanisms that control SR Ca release are aided by methods that permit estimating the Ca permeability of the SR membrane or, equivalently, the extent of activation of the SR Ca release channels. This quantity is proportional to the rate of Ca ...

An improved and updated version of the statistical LOWESS fit to the marine Sr/Sr record and a revised look-up table (V3:10/99; available from [email protected]) based upon it enables straightforward conversion of Sr/Sr to numerical age, and vice versa, for use in strontium isotope stratigraphy (SIS). The table includes 95% confidence intervals on predictions of numerical age from Sr/Sr. Thi...

BACKGROUND The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile. Scavenger receptor class B type I (SR-BI) binds HDL and mediates selective uptake of cholesterol ester and cellular efflux of cholesterol to HDL. The role of SR-BI i...

Analysis of several well-documented specimens from each of the three volcanic series on Oahu gives the following mean ratios of Sr(87) to Sr(86): the Waianae series, 0.7030 +/- 0.00010 (sigma); the Koolau series, 0.70385+/- 0.00009 (sigma); and the Honolulu series, 0.7029 ++/- 0.00006 ( sigma). The mean ratio of Sr(87) to Sr(86) of the Koolau series specimens is significantly higher than the me...

Let Sr(∆) be the module of all splines of smoothness r on the rectilinear partition ∆ which subdivides some domain D. Further, let Sr(Γ) be the module of all splines of smoothness r on Γ which also subdivides D, where Γ is a finer subdivision of ∆. We study the relationship between a generating set of Sr(∆) and a generating set for Sr(Γ). This paper gives an algorithm for extending a generating...

The fact that animal introns are not spliced out in plants suggests that recognition of pre-mRNA splice sites differs between the two kingdoms. In plants, little is known about proteins required for splicing, as no plant in vitro splicing system is available. Several essential splicing factors from animals, such as SF2/ASF and SC-35, belong to a family of highly conserved proteins consisting of...

OBJECTIVE The di-leucine motif exists in the intracellular domains of certain cell surface receptors, participating in the receptor-mediated endocytosis. The present study was aimed at determining the role of the di-leucine motif in class A scavenger receptor (SR-A)-mediated ligand endocytosis. METHODS AND RESULTS cDNA coding for a mutant (SR-A mutant N3132LM) with deletion of the di-leucine ...

Although Ca/calmodulin-dependent protein kinase-II (CaMK) is known to phosphorylate different Ca cycling proteins in the cardiac sarcoplasmic reticulum (SR) and regulate its function, the status of CaMK in heart failure has not been investigated previously. In this study, we examined the hypothesis that changes in the CaMK-mediated phosphorylation of the SR Ca cycling proteins are associated wi...