PURPOSE DX-8951f is a novel hexacyclic camptothecin-analogue topoisomerase I inhibitor with both in vitro antileukemic activity and myelosuppression as a dose-limiting toxicity in solid tumor Phase I studies. DX-8951f is active in a human acute myeloid leukemia (AML) severe combined immunodeficient mouse model. In a leukemia Phase I study, we investigated the toxicity profile and pharmacokineti...

Let $\Omega\subset\mathbb{R}^2$ be a smooth bounded domain with $0\in\partial\Omega$. In this paper, we prove that for any $\beta\in(0,1)$, the supremum $$\sup_{u\in W^{1,2}(\Omega), \int_\Omega u dx=0, \int_\Omega|\nabla u|^2dx\leq1}\int_\Omega \frac{e^{2\pi(1-\beta) u^2}}{|x|^{2\beta}}dx$$ is finite and can attained. This partially generalizes well-known work of Alice Chang Paul Yang (J. Diff...

The conversion of biomass into fuel under typical refinery conditions is a promising solution to decrease carbon footprint. Herein we convert representative compound new bio-petroleum, DX (1,2:3,5-di-O-isopropylidene-α-D-xylofuranose) mixture with n-hexane. Firstly fresh zeolites (Beta, ZSM-5 and USY) were explored. Beta zeolite showed high performance in converting hydrocarbons. Thus it was fu...

It is shown in this paper that suitable weak solutions to the 6D steady incompressible Navier-Stokes are H\"{o}lder continuous at $0$ provided $\int_{B_1}|u(x)|^3dx+\int_{B_1}|f(x)|^qdx$ or $\int_{B_1}|\nabla u(x)|^2dx$+$\int_{B_1}|\nabla u(x)|^2dx\left(\int_{B_1}|u(x)|dx\right)^2+\int_{B_1}|f(x)|^qdx$ with $q>3$ sufficiently small, which implies 2D Hausdorff measure of set singular points zero...

In 1997 the author published an article on vertical full (and ground plane type half) wave loops for 80 meter DX. In that article it was noted that perpendicular (horizontal) polarization is the preferred polarization, particularly at low elevation angles, since horizontally polarized waves are hardly affected by the finite conductivity of the ground in front of the antenna. An exception when v...

AIM To evaluate molecular mechanisms of tissue-protective effects of antioxidants selenomethionine (SeMet) and D-pantethine (D-Pt) applied in combination with doxorubicin (Dx) in B16 melanoma-bearing-mice. METHODS Impact of the chemotherapy scheme on a survival of tumor-bearing animals, general nephro- and hepatotoxicity, blood cell profile in vivo, and ROS content in B16 melanoma cells in vi...

• State-F: Forward Outliers p(dx|Zx,mx = 1) = Uf (dx|Zx) = Uf · 1[dtxZx]. For the purpose to combine all the three states into a united model and describe the overall likelihood that the input depth samples fit the current static structure, we use a mixture model similar to the Gaussian Mixture Model [1]. Together with ...