The mechanisms by which the diffusion rate in the plasma membrane (PM) is regulated remain unresolved, despite their importance in spatially regulating the reaction rates in the PM. Proposed models include entrapment in nanoscale noncontiguous domains found in PtK2 cells, slow diffusion due to crowding, and actin-induced compartmentalization. Here, by applying single-particle tracking at high t...

MSK-C3H-NU, a cloned mouse epidermal keratinocyte cell line, was established from the epidermis of C3H/HeN mammary tumor virus-positive nude mice. Although it has lost its diploid chromosome number, the cell line is nontumorigenic, has been stable during serial subcultivations for over 2 years, and has retained some differentiated biological characteristics of normal keratinocytes. MSK-C3H-NU c...

ABSTRACT Minimum Shift Keying (MSK) is considered to be a spectrally efficient modulation scheme, in comparison with other families of constant envelope modulation. However, its main sidelobe can be of some worry in digital data transmission, particularly over nonlinear channels. Therefore, it is practically of interest to search for efficient pulse shaping schemes, largely proposed either thro...

Specific data on different musculoskeletal (MSK) disorders from the Global Burden of Disease (GBD) study will be presented in this and future issues of the journal. MSK disorders are the second most common cause of disability worldwide, measured by years lived with disability (YLDs), with low back pain being the most frequent condition. Disability due to MSK disorders is estimated to have incre...

c t f u r pain. This did not occur following general walking exercise, Do you know that we should start looking at the brain when treating musculoskeletal disorders (MSKD) and that exercises can potentially train the brain? Given the high prevalence, impact, and burden of MSKD,1 therapies need to focus on the origin of the problem to be more effective and reduce the economical expenses of these...

BACKGROUND Musculoskeletal (MSK) disorders represent a great burden on the health care system. The use of physiotherapists in their autonomous roles and in advanced practice roles may help increase access to care. Thus, the aim of this survey was to assess the perceptions of a university community sample within the province of Quebec about physiotherapists as primary care practitioners and adva...

Activation of the extracellular signal-regulated kinase (ERK) signaling pathway in the striatum is crucial for molecular adaptations and long-term behavioral alterations induced by cocaine. In response to cocaine, ERK controls the phosphorylation levels of both mitogen and stress-activated protein kinase 1 (MSK-1), a nuclear kinase involved in histone H3 (Ser10) and cAMP response element bindin...