به دلیل عدم قطعیت‌های شناختی، تصادفی و محدودیت‌های انعطاف پذیر، در این مطالعه مدل جدیدی از برنامه‌ریزی محدودیت شانس انعطاف‌پذیر، امکانی، استوار مختلط بر مبنای تئوری اعتبار برای طراحی شبکه زنجیره تامین حلقه بسته توسعه داده شد. نگرش‌های متفاوت تصمیم‌گیرندگان با اندازه‌گیری انعطاف‌پذیرتر پارامترهای خوش‌بینانه بدبینانه قالب معیار پاسخ حداقل سطح رضایت انعطاف‌پذیر حل بهینه گردید. پیشنهادی، قادر کاهش ...

امروزه به­ دلیل شتاب روزافزون روند جهانی‌سازی در سراسر دنیا زنجیره تأمین ابعاد جدید به خود گرفته و بسیار پیچیده‌تر از قبل شده است. هوشمند باید طریق فناوری‌های مختلف به­خصوص اینترنت بتواند امکان تبادل اطلاعات سریع کل زنجیره‌ را فراهم کند. پژوهش حاضر یک مطالعه کیفی به­منظور ارائه مدل برای خدمات صندوق کارآفرینی امید صورت این روش داده‌بنیاد اشتراوس کوربین (1998)، استفاده تا اشباع نظری مصاحبه‌شوندگا...

Phosphorus (P) acts as one of the essential macronutrients and plays critical roles in regulating growth, development, yield formation capacity crop plants. Elucidating physiological molecular processes underlying plant P deprivation responses benefit cultivation with high use efficiency (PUE). In this study, we investigated P-associated agronomic traits well transcriptome profile under contras...

Because they generate excellent images, nanoparticles (NPs), especially biosynthesized NPs, provide a new solution for tumor imaging. In this research, we unveil a novel type of biosynthesized NPs featuring multicolor fluorescence. These NPs exhibit little cytotoxicity to cells. The explored NPs, designated Zn-ZFP-GST NPs (Zinc NPs in abbreviation), are generated from leukemia cells treated wit...

The KRAB-zinc finger proteins (KRAB-ZFPs) represent a very large, but poorly understood, family of transcriptional regulators in mammals. They are thought to repress transcription via their interaction with KRAB-associated protein 1 (KAP1), which then assembles a complex of chromatin modifiers to lay down histone marks that are associated with inactive chromatin. Studies of KRAB-ZFP/KAP1-mediat...

Zinc finger protein 809 (ZFP809) is a member of the Kruppel-associated box-containing zinc finger protein (KRAB-ZFP) family, and is highly expressed in mouse immature cells. ZFP809 is known to inhibit the expression of transduced genes driven by Moloney murine leukemia virus (MoMLV)-typed retroviral vectors by binding to the primer binding site (PBS) located downstream of the MLV-long terminal ...

MicroRNAs (miRNAs) are small regulatory RNAs targeting multiple effectors of cell homeostasis and development, whose malfunctions are associated with major pathologies such as cancer. Herein we show that GAM/ZFp/ZNF512B works within an intricate gene regulatory network involving cell-cycle regulators, TGFβ effectors and oncogenic miRNAs of the miR-17-92 cluster. Thus, GAM impairs the transcript...

In an earlier greenhouse screening, we identified a local indica cultivar HT54 tolerant to high temperature at both seedling and grain-filling stages. In this study, we develop an optimized procedure for fine assessment of this heat tolerance. The results indicated that HT54 seedlings could tolerate high temperature up to 48 °C for 79h. The genetic analysis of F(1) and F(2) offspring derived fr...

Seed germination is controlled by environmental signals, including light and endogenous phytohormones. Abscisic acid (ABA) inhibits, whereas gibberellin promotes, germination and early seedling development, respectively. Here, we report that ZFP3, a nuclear C2H2 zinc finger protein, acts as a negative regulator of ABA suppression of seed germination in Arabidopsis (Arabidopsis thaliana). Accord...

Arsenic is a carcinogenic element also used for the treatment of acute promyelocytic leukemia. The reactivity of proteins to arsenic must be associated with the various biological functions of As. Here, we investigated the selectivity of arsenite to zinc finger proteins (ZFPs) with different zinc binding motifs (C2H2, C3H, and C4). Single ZFP domain proteins were used for the direct comparison ...