20 Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G-protein coupled 21 somatostatin receptors (SSTRs), of which 5 isoforms exist (SSTR1-5). In mice, the effects on 22 pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, 23 SSTR activation results in membrane hyperpolarisation and suppression of exocytosis. Here we 24 examined ...

[1] A suite of idealised ensemble experiments are used to investigate the sensitivity of the Southern Hemisphere atmospheric circulation to the location of SST anomalies over the tropical Pacific Ocean. Of particular interest is the response of South American rainfall during austral summer. The experiments reveal an approximately opposite response in rainfall over South America when the tropica...

Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR activation results in membrane hyperpolarization and suppression of exocytosis. Here, we examined the mechani...

In this validation work two turbulence models (k-ε and SST model) and two grids (a finer hybrid grid and a tetrahedral coarser grid) are considered in order to model helium release and dispersion. Simulation results are compared against an experiment of jet release phenomena in the Battelle Model Containment facility (BMC), a multi-compartment facility with a total volume of about 560 m. In the...

Reliable reconstruction of past sea surface temperature (SST) is prime importance for understanding the Earth’s sensitivity to external forcing. Yet, it remains a major challenge in paleoceanography because comparison between SST estimates from different proxies reveals mismatches and raise question as what contrasting actually record. A better these light seasonal occurrence proxy bearing orga...