The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial ce...

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Structural defects and the diagnosis of amyloidogenic propensity,” by Ariel Fernández, József Kardos, L. Ridgway Scott, Yuji Goto, and R. Stephen Berry, which appeared in issue 11, May 27, 2003, of Proc Natl Acad Sci USA (100:6446–6451; first published May 12, 2003; 10.1073/ pnas.0731893100). The undersigned authors note the following: “We wi...

APE1/Ref-1 is thought to be a multifunctional protein involved in reduction-oxidation (redox) regulation and base excision DNA repair, and is required for early embryonic development in mice. APE1/Ref-1 has redox activity and AP endonuclease activity, and is able to enhance DNA-binding activity of several transcription factors, including NF-kappaB, AP-1 and p53, through reduction of their criti...

The bacteriophage P1 Ref (recombination enhancement function) protein is a RecA-dependent, HNH endonuclease. It can be directed to create targeted double-strand breaks within a displacement loop formed by RecA. The 76 amino acid N-terminal region of Ref is positively charged (25/76 amino acid residues) and inherently unstructured in solution. Our investigation of N-terminal truncation variants ...

This article describes the development of a measure of schizotypic referential thinking. The authors present a 34-item questionnaire that includes a wide variety of referential thoughts and experiences, including both simple and guilty ideas of reference. The Referential Thinking Scale (REF) displays adequate internal consistency and strong relations with other measures of Schizotypy, such as t...

Previous studies have shown that, in natural French populations of Drosophila melanogaster, 10 to 20% of the flies are infected by the noncontagious, hereditary rhabdovirus sigma responsible for CO(2) sensitivity. These populations are also polymorphic for two alleles [ref(2)P(o) and ref(2)P(p)] of a gene for resistance to the sigma virus. Evidence is given here that two viral genetic types, di...

A performance-based funding system like the United Kingdom's 'Research Excellence Framework' (REF) symbolizes the re-rationalization of higher education according to neoliberal ideology and New Public Management technologies. The REF is also significant for disclosing the kinds of behaviour that characterize universities' response to government demands for research auditability. In this paper, ...

The energy constrained wireless sensor nodes need very efficient localization algorithm for event detection. We propose a method for localizing the wireless sensor nodes using the concept of Cayley-Menger Determinants, which in turn uses a quadratic solver. This is a modification of the method proposed in Ref. [5]. Cayley-Menger Detereminants are used to introduce corrections to the noisy measu...

Herpes simplex virus type 1 (HSV-1) protein ICP27 interacts with the cellular export adaptor protein Aly/REF, which is part of the exon junction complex implicated in cellular mRNA export. We previously reported that Aly/REF was no longer associated with splicing factor SC35 sites during infection but instead colocalized with ICP27 in distinct structures. Here we show that these structures colo...

Much of the patterning of early C. elegans embryos involves a series of Notch interactions that occur in rapid succession and have distinct outcomes; however, none of the targets for these interactions have been identified. We show that the REF-1 family of bHLH transcription factors is a major target of Notch signaling in all these interactions and that most examples of Notch-mediated transcrip...