This study focused on the intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (MTS). The nanocarriers showed an efficient cellular uptake, and the MTS had a positive effect on their mitochondrial targeting. This is the first report of an intracellular observation of nanocarriers modified with MTS.

BACKGROUND Mitotic and meiotic spindles are assemblies of microtubules (MTs) that form during cell division to physically separate sister chromosomes. How the various components of spindles act together to establish and maintain the dynamic bipolar structure of spindles is not understood. Interactions between MTs and motors have been studied both experimentally and theoretically in many context...

STUDY DESIGN Cross-sectional study. OBJECTIVE To explore the underlying anatomy of May-Thurner syndrome (MTS) using computed tomography (CT) and discuss its clinical significance for typing diagnosis. SUMMARY OF BACKGROUND DATA Because the anatomical position of the corpse cannot fully illustrate the actual clinical situation in vivo, the diversity of MTS has not been fully elucidated yet. ...

Prometaphase in two large species of diatoms is examined, using the following techniques: (a) time-lapse cinematography of chromosome movements in vivo; (b) electron microscopy of corresponding stages: (c) reconstruction of the microtubules (MTs) in the kinetochore fiber of chromosomes attached to the spindle. In vivo, the chromosomes independently commence oscillations back and forth to one po...

Temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (TLE + uMTS) have been demonstrated to have extensive white matter abnormalities both ipsilateral and contralateral to the seizure onset zone. However, comparatively less is known about the white matter integrity of TLE patients without MTS (non-lesional TLE, nl-TLE). The purpose of the study was to investigate the diffus...

Microtubules (MTs) are dynamic polymers that can exist in phases of elongation and rapid-shortening at steady-state. These phases have been observed in vitro and in living cells, and this property of MTs has been termed 'dynamic instability'. The purpose of this study was to use negative-stain electron microscopy (EM) to test if there are structural differences between the ends of MTs in the el...

We consider the extensions of modal transition systems (MTS), namely Boolean MTS and parametric MTS and we investigate the refinement problems over both classes. Firstly, we reduce the problem of modal refinement over both classes to a problem solvable by a QBF solver and provide experimental results showing our technique scales well. Secondly, we extend the algorithm for thorough refinement of...

Multi-standard mobile devices are allowing users to enjoy higher data rates and ubiquitous connectivity. These advances are achieved on the expense of higher energy consumption requirements due to the continuous connectivity and the multiple active wireless interfaces. In this article, we use one advantage of the multiple interfaces, namely short-range (SR) communications. Mobile terminals (MTs...

At present, the laboratory diagnosis of intestinal infections caused by microsporidia depends on the detection of the typical spores either with a modified trichrome stain (MTS) or by staining with fluorochromes. The purpose of the present study was (i) to compare staining with MTS (MTS method) and the staining with the fluorochrome Uvitex 2B (U2B method) with respect to their sensitivities and...

We describe the design and implementation of a collaborative, computer-based finger painting program for children using a new hardware input device called a MultiTouch Surface (MTS). The MTS uses a flat surface about the size of a keyboard to track multiple, simultaneous finger motions, which we transform into paint strokes on a screen. We describe related work and explain how our program desig...