Gene transcription is required for long-term memory (LTM) formation. LTM formation is impaired in a male-specific manner in mice lacking either of the two Ca(2+)/calmodulin-dependent kinase kinase (Camkk) genes. Since altered transcription was suggested to cause these impairments in LTM formation, we used microarrays to screen for CaMKKbeta-dependent gene expression changes. Here we show that t...

Many working memory (WM) models propose that the focus of attention (or primary memory) has a capacity limit of one to four items, and therefore, that performance on WM tasks involves retrieving some items from long-term (or secondary) memory (LTM). In the present study, we present evidence suggesting that recall of even one item on a WM task can involve retrieving it from LTM. The WM task requ...

The mere presence of irrelevant external stimuli results in interference with the fidelity of details retrieved from long-term memory (LTM). Recent studies suggest that distractibility during LTM retrieval occurs when the focus of resource-limited, top-down mechanisms that guide the selection of relevant mnemonic details is disrupted by representations of external distractors. We review finding...

Calcium/calmodulin-dependent kinases (CaM-kinases) are central to various forms of long-term memory (LTM) in a number of evolutionarily diverse organisms. However, it is still largely unknown what contributions specific CaM-kinases make to different phases of the same specific type of memory, such as acquisition, or early, intermediate, and late consolidation of associative LTM after classical ...

Abstract We investigated the nanoionics-based neuromorphic function of Pt/Ti0.96Co0.04O2-δ/Pt multilayer with cross-point structure prepared by RF magnetron sputtering. This exhibits electro-ion mixed conduction and nonlinear current-voltage characteristic based on Schottky barrier between Pt Ti0.96Co0.04O2-δ layers. When low electrical pulse 0.8 V was applied short interval time 14 s, current ...

Recent theories suggest that performance on working memory (WM) tasks involves retrieval from long-term memory (LTM). To examine whether WM and LTM tests have common principles, Craik and Tulving's (1975) levels-of-processing paradigm, which is known to affect LTM, was administered as a WM task: Participants made uppercase, rhyme, or category-membership judgments about words, and immediate reca...

Extensive evidence suggests that long term memory (LTM) formation is dependent on the activation of neuronal second messenger systems and requires protein synthesis. The cAMP response element binding protein (CREB) is a constitutively expressed regulatory transcription factor that couples changes in second messenger levels to changes in cellular transcription. Several recent studies suggest tha...

To discover semantically coherent topics from topic models, knowledge-based topic models have been proposed to incorporate prior knowledge into topic models. Moreover, some researchers propose lifelong topic models (LTM) to mine prior knowledge from topics generated from multi-domain corpus without human intervene. LTM incorporates the learned knowledge from multi-domain corpus into topic model...

Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The iso-MGS biosynthetic machinery featured an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes (MgsIJK). We now ...

Abstract Critical cascades are found in many self-organizing systems. Here, we examine critical as a design paradigm for logic and learning under the linear threshold model (LTM), simple biologically inspired variants of it sources computational power, efficiency, robustness. First, show that LTM can compute logic, with small modification, universal Boolean examining its stability cascade frequ...