Objective(s): In the present study, C57BL/6 female mice (n=56) were used to explore the neuroprotective effects of riboflavin in motor disability of experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis. Materials and Methods: The animals were assigned into 7 groups: sham-operated 1 (SO1), healthy mice receiving PBS (phosphate buffer saline); sham-operated 2 (SO2), h...

Background: IL-17/IL-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). The immunomodulatory properties of ginger are reported in previous studies. Objective: To evaluate the effects of ginger extract on the expression of IL-17 and IL-23 in a model of EAE. Methods: EAE was induc...

Abstract Monocyte recruitment into the central nervous system (CNS) is critical for driving pathology in neuroinflammatory diseases such as MS. The monocytic influx well activation of resident myeloid cells contribute to and subsequent re-activation autoreactive T cells, ultimately leading demyelinating lesions, axonal damage, progressive paralysis. Using murine model MS, experimental autoimmun...

Multiple sclerosis (MS) is a chronic neuroinflammatory demyelinating disorder of the central nervous system with unclear exact etiology. The experimental autoimmune encephalomyelitis (EAE) model in C57BL/6 mice most common animal for MS sharing many clinical and pathophysiological features to expand our knowledge on pathophysiology disease develop novel treatment strategies. current study was p...

Rice farming in coastal areas is often victim to flooding as a result of climate change. Low-cost adaptation strategies are required increase resilience and rice productivity these flood-prone areas. In this study, enriched Azolla extract (EAE) liquid biofertilizers, combined with selected stress-tolerant varieties, were tested farmers’ fields Pangandaran, West Java from June October 2020. This...

OBJECTIVE To estimate the cost-effectiveness of treating patients with a venous leg ulcer (VLU) with an externally applied electroceutical (EAE) device, plus dressings and compression bandaging or continuing with their previous care plan, from the perspective of the National Health Service (NHS) in the UK. METHOD This was a prospective, single-arm, non-blinded, clinical and economic evaluatio...

multiple sclerosis (ms) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. one of the best animal models of demyelinating diseases is experimental autoimmune encephalomyelitis (eae), which can be induced in a variety of animals by injection of a target antigen such as myelin basic protein (mbp). the immune responses against the target amino acids cause tis...

We developed a quick genetic approach to screen variants of the intimin gene (eae) by using a heteroduplex mobility assay (HMA) that targets the 5' conserved region of eae. The eae variants were categorized into 4 major HMA types and 10 minor subtypes.

background: il-17/il-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms). the immunomodulatory properties of ginger are reported in previous studies. objective: to evaluate the effects of ginger extract on the expression of il-17 and il-23 in a model of eae. methods: eae was induce...