The surface levels of major histocompatibility complex class I antigens are diminished on tumorigenic adenovirus type 12 (Ad12)-transformed cells, enabling them to escape from immunosurveillant cytotoxic T lymphocytes (CTLs). This is due to the down-regulation of the class I transcriptional enhancer, in which there is strong binding of the repressor COUP-TFII and lack of binding of the activato...

The author explores the different temporalities of developmental time, après-coup and what she calls 'reverberation time'. She considers the paradoxical temporality of the 'here and now', showing that it is not pure present, and describes at the micro-level of sessional material how progressive and retrospective time go inherently together, one being a requisite for the other.

When the head is subject to non-penetrating (blunt) impact, contusion-type injuries are commonly identified beneath the impact site (the coup) and, in some instances, at the opposite pole (the contre-coup). This pattern of injury has long eluded satisfactory explanation and blunt head injury mechanisms in general remain poorly understood. There are only a small number of studies in the open lit...

Abstract This paper offers a novel illustration of the political economy religion by examining impact religious elites on development. We compile unique database holy Muslim shrines across Pakistani Punjab and construct historical panel literacy spanning over century (1901–2011). Using 1977 military takeover as universal shock that gave control public goods to politicians, our difference-in-dif...

Clara cell 10 kD protein (CC10) is expressed specifically in a portion of nonciliated airway epithelial cells. The molecular mechanisms that determine its high specificity are not clear. Transcription factors implicated in the regulation of CC10 in rodents do not show the same level of cell specificity. We report here that a 3.3 kb human CC10 DNA fragment, containing the 5' flanking region and ...

The coumarin antibiotic coumermycin A(1) contains at least eight methyl groups, presumably derived from S-adenosylmethionine. Two putative methyltransferase genes, couO and couP, of the coumermycin A(1) biosynthetic gene cluster were inactivated by in-frame deletion. In the resulting mutants, coumermycin A(1) production was abolished. New coumermycin derivatives were accumulated instead, and we...

Parallel systems are limited by the high costs of communication and synchronization. Exploiting commutativity has historically been a fruitful avenue to reduce traffic and serialization. This is because commutative operations produce the same final result regardless of the order they are performed in, and therefore can be processed concurrently and without communication. Unfortunately, software...

Why do coups happen and how can state leaders affect their likelihood? Existing research focuses on structural factors as well “coup-proofing” drivers of coup risk. I argue that the literature misses an important alternative avenue by which likelihood militaries remove them from office: adding or removing military officers government. When bring into government, they signal to there is a peacef...