Metoclopramide hydrochloride is a widely used medication for the treatment of gastrointestinal disorders such as nausea, vomiting, and gastroparesis. However, it has been associated with extrapyramidal side effects (EPS) tardive dyskinesia, nystagmus, other locomotive on rare occasions. These reactions are commonly seen in children females, particularly young people. In this article, we report ...

The rate of paracetamol absorption depends on the rate of gastric emptying. Propantheline delayed gastric emptying and markedly slowed the absorption of paracetamol in six convalescent hospital patients. Conversely, the absorption of paracetamol in five healthy volunteers was accelerated by metoclopramide, a drug which stimulates gastric emptying. The total 24-hour urinary excretion of paraceta...

The action of metoclopramide on gastroduodenal motility was studied in 23 subjects: eight symptomless volunteers and 15 patients with varying upper abdominal conditions. The response depended on the basal contraction pattern before the drug was given, irrespective of the clinical diagnosis. The size of the antral contractions was consistently increased and the duodenal contractions became more ...

The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure (LOSP) were studied in 12 healthy volunteers using oesophageal pressure transducers. Atropine decreased LOSP significantly at 5 min after i.v. injection (P less than 0.005) and this change was sustained for 60 min. Metoclopramide increased LOSP significantly at 3 min after administration i.v. (P less than 0.0...

The objective of this study was to evaluate the physical and chemical stability of mixtures of undiluted palonosetron hydrochloride 50 micrograms/mL with undiluted metoclopramide hydrochloride 5 mg/mL and with promethazine hydrochloride 2 mg/mL diluted in 5% dextrose injection during simulated Y-site administration. Triplicate test samples were prepared by admixing 7.5 mL of palonosetron hydroc...

We have studied the antiemetic efficacy of droperidol alone, and in combination with metoclopramide in first trimester termination of pregnancy in day surgery. The aim was to determine whether the addition of metoclopramide could further reduce the incidence of postoperative nausea and vomiting (PONV) but avoid excessive sedation. Group I (control, n = 40) received i.v. droperidol 0.625 mg at i...

AIM: To compare qualitatively Metoclopramide, Ondansetron and Granisetron alone and in combination with Dexamethasone in the Prevention of Postoperative Nausea and Vomiting in Day Care Laparoscopic Gynaecological Surgery under General Anaesthesia. METHOD: 180 adult female patients of ASA Grade I and II, BMI <30, aged 18 to 55 years undergoing laparoscopic gynaecological surgery under general an...