I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated PlusMaze” by Komaki et al. (2015). In this valuable article, the authors uncovered the effects of AM251 as a CB1 receptor antagonist on anxiety-like behaviors of rats using elevated plus-maze. However, I have a few comments on thi...

This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-alpha) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-alpha release through anandamide-activation of hypothalamic cannabinoid receptor CB(...

Cannabinoid type 1 Receptor (CB1) belongs to the GPCR family and it has been targeted, so far, for the discovery of drugs aimed at the treatment of neuropathic pain, nausea, vomit, and food intake disorders. Here, we present the development of the first fluorescent assay enabling the measurement of kinetic binding constants for CB1 orthosteric ligands. The assay is based on the use of T1117, a ...

At Eurocrypt ’06, Nguyen and Regev presented a new key-recovery attack on the GoldreichGoldwasser-Halevi (GGH) lattice-based signature scheme: when applied to NTRUSign-251 without perturbation, the attack recovers the secret key given only 90,000 signatures. At the rump session, Whyte speculated whether the number of required signatures might be significantly decreased to say 1,000, due to the ...

In (1a) the verb is final in its main clause and must therefore occur in the disjoint form, marked by the prefix -la-. In (1b), the answer to the question in (1a), the verb occurs in the conjoint form, which lacks the -laprefix, since the verb is presupposed and ‘cigarettes’ is in focus. A table of Chibemba conjoint/disjoint forms is provided from Hyman & Watters (1948: 251) in (2) from Hyman &...

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Naoki Takeshita1*, Yo Kajiyama1, Yuma Morishita1, Toshiyuki Itoi1, Masaaki Yamagishi2, and Tsugutoshi Suzuki3 Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan; Department of Pediatric Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kam...