The antisecretory effects of several Y agonists, including pancreatic polypeptide (PP), indicate the presence of Y(1), Y(2), and Y(4) receptors in mouse and human (h) colon mucosae. Here, we used preparations from human and from wild-type (WT), Y(4), and Y(1) receptor knockout ((-/-)) mice, alongside Y(4) receptor-transfected cells to define the relative functional contribution of the Y(4) rece...

Autoregulation of renal blood flow comprises three mechanisms: the myogenic response (MR), the tubuloglomerular feedback (TGF), and a third mechanism (3M). The nature of 3M is unknown; it may be related to hypotensive resetting of autoregulation that probably relies on pressure-dependent stimulation of the renin-angiotensin system (RAS). Thus we used a normotensive angiotensin II clamp in anest...

soil is known as the base material for many structure, on the other hand, some soils cause problems for some structures such as roads. some types of soils absorb moisture and swell then they may shrink when losing water. the changes of moisture in these soil samples cause changes their volume and pressure to layers of the pavement and eventually leads to destruction of roads. therefore, it is n...

AIMS/INTRODUCTION As reports show cardiovascular (CV) risks in first-degree relatives (FDR) of type 2 diabetics, and autonomic imbalance predisposing to CV risks, in the present study we have assessed the contribution of sympathovagal imbalance (SVI) to CV risks in these subjects. MATERIALS AND METHODS Body mass index (BMI), waist-to-hip ratio (WHR), basal heart rate (BHR), blood pressure (BP...

We studied the renin and the circulatory responses to unilateral reduction of the renal perfusion pressure (RPP) in seven normotensive subjects and 17 patients with primary hypertension who required diagnostic renal angiography. A balloon-tipped catheter was used for occlusive arteriography; the same catheter was also used to reduce, through appropriate inflation of the balloon, the RPP by 50% ...

Although neuropeptide Y (NPY) is established as a transmitter in many regions of the nervous system, the role of other peptides of the pancreatic polypeptide (PP) family in the CNS is obscure. This study provides evidence that PP-like peptides in the "primitive" CNS of a cyclostome are composed of different molecular forms, which are stored in separate neuronal populations with apparently diffe...

BACKGROUND In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. METHODS AND RESULTS In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arte...

Vitamin D may protect against cardiovascular disease, but its association with cardiac function is unclear. The aim of this study was to examine the associations of serum 25-hydroxyvitamin D (25[OH]D) with heart rate, systolic blood pressure, and the rate-pressure product (RPP). Data analyses were carried out on 27,153 participants aged > or =20 years, with measurements of serum 25(OH)D, heart ...

OBJECTIVE Allium hirtifolium (Persian shallot) has a hypoglycemic effect on diabetic animals. The aim of this study was to assess the effect of the ethyl acetate fraction of Allium hirtifolium on the function of isolated hearts of diabetic rats. METHODS The control and diabetic animals were randomly divided into four groups: saline- or extract-treated controls (n=10 and n=6, respectively) and...