Huang, An, Dong Sun, Carolyn J. Smith, Joseph A. Connetta, Edward G. Shesely, Akos Koller, and Gabor Kaley. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am. J. Physiol. Heart Circ. Physiol. 278: H762–H768, 2000.—The mechanisms that account for acetylcholine (ACh)-induced responses of skeletal muscle arterioles of mice lacking endothelial nitric...

Miyata, Yukio, Shigeaki Muto, Satoru Yanagiba, and Yasushi Asano. Extracellular Cl2 modulates shrinkageinduced activation of Na1/H1 exchanger in rat mesangial cells. Am J Physiol Cell Physiol 278: C1218–C1229, 2000.—To examine the effect of hyperosmolality on Na1/H1 exchanger (NHE) activity in mesangial cells (MCs), we used a pHsensitive dye, 28,78-bis(2-carboxyethyl)-5(6)-carboxyfluorescein-AM...

Roczniak, Agnes, David Z. Levine, and Kevin D. Burns. Localization of protein inhibitor of neuronal nitric oxide synthase in rat kidney. Am J Physiol Renal Physiol 278: F702–F707, 2000.—We have recently demonstrated that in rats with 5/6 nephrectomy (5/6 Nx), renal cortical and inner medullary neuronal NOS (nNOS) expression is downregulated, associated with decreased urinary excretion of nitric...

Canal-Corretger, M. M., T. Cambras, J. Vilaplana, and A. Dı́ez-Noguera. Bright light during lactation alters the functioning of the circadian system of adult rats. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R201– R208, 2000.—To examine the role of light in the maturation of the circadian pacemaker, twelve groups of rats were raised in different conditions of exposure to constant ...

Pfeffer, Lawrence M., Chuan He Yang, Susan R. Pfeffer, Aruna Murti, Shirley A. McCormack, and Leonard R. Johnson. Inhibition of ornithine decarboxylase induces STAT3 tyrosine phosphorylation and DNA binding in IEC-6 cells. Am. J. Physiol. Cell Physiol. 278: C331–C335, 2000.—Polyamines are required for the proliferation of the rat intestinal mucosal IEC-6 cell line. Ornithine decarboxylase (ODC)...

Weber, Jean-Michel, and Deena S. Shanghavi. Regulation of glucose production in rainbow trout: role of epinephrine in vivo and in isolated hepatocytes. Am J Physiol Regulatory Integrative Comp Physiol 278: R956–R963, 2000.— The rate of hepatic glucose production (Ra glucose) of rainbow trout (Oncorhynchus mykiss) was measured in vivo by continuous infusion of [6-3H]glucose and in vitro on isola...

Chupreta, Sergey, Ming Du, Andrea Todisco, and Juanita L. Merchant. EGF stimulates gastrin promoter through activation of Sp1 kinase activity. Am J Physiol Cell Physiol 278: C697–C708, 2000.—Epidermal growth factor (EGF) receptor activation stimulates gastrin gene expression through a GC-rich element called gastrin EGF response element (gERE). This element is bound by Sp1 family members and is ...

Busk, Morten, Frank B. Jensen, and Tobias Wang. Effects of feeding on metabolism, gas transport, and acid-base balance in the bullfrog Rana catesbeiana. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R185–R195, 2000.—Massive feeding in ectothermic vertebrates causes changes in metabolism and acid-base and respiratory parameters. Most investigations have focused on only one aspect of...

TAMAE YODA,1 LARRY I. CRAWSHAW,2 KYOKO YOSHIDA,1 LIU SU,1 TAKAYOSHI HOSONO,2 OSAMU SHIDO,3 SOTARO SAKURADA,3 YUTAKA FUKUDA,1 AND KAZUYUKI KANOSUE2 1Department of Physiology and Biosignalling, Graduate School of Medicine, Osaka University, Osaka; 2Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Osaka 565-0871; and 3Department of Physiology, Schoo...

Polychlorinated biphenyls (PCBs) and the structurally related polybrominated diphenyl ethers (PBDEs) are abundant persistent organic pollutants that exert several comparable neurotoxic effects. Importantly, hydroxylated metabolites of PCBs and PBDEs have an increased neurotoxic potency. Recently, we demonstrated that PCBs can act as (partial) agonist on GABAA neurotransmitter receptors, with PC...