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Naturally occurring proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) form amyloid fibrils in seminal fluid, which capture HIV virions and promote infection. For example, PAP248-286 fibrils, termed SEVI (semen-derived enhancer of viral infection), can potentiate HIV infection by several orders of magnitude. Here, we design three disr...

We assessed hippocampal-dependent memory in mice with a Ca(2+)-independent form of CaMKII generated by the introduction of an aspartate at amino acid 286. The CaMKII-Asp-286 mice show normal LTP at high frequency stimulation, but in the 5-10 Hz range, they show a shift in the frequency-response curve favoring LTD. This range of frequencies is similar to the theta rhythm, which is associated wit...

Reaction-induced changes of the morphology of a Pt foil catalyst during ammonia oxidation were investigated in a temperature-controlled way for partial pressures of oxygen and ammonia around 4.5 and 3 kPa, respectively, and at temperatures between 20 and 700 8C. The presence of the feed mixture (ammonia and oxygen) was required to induce surface roughening. Moreover, the reaction temperature co...

Two simple UV-Spectrophotometric methods have been developed for simultaneous determination of Rosuvastatin calcium and Fenofibrate in pharmaceutical formulation. Methanol AR grade was used as solvent. In Method-I (Qabsorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 255.99 nm (isoabsorptive point) and 286 nm (λ max of Fenofibrate). While, in Method-...

In the present paper, we shall give necessary and sufficient conditions for the strong and weak boundedness of the Riesz potential operator [Formula: see text] on Orlicz spaces. Cianchi (J. Lond. Math. Soc. 60(1):247-286, 2011) found necessary and sufficient conditions on general Young functions Φ and Ψ ensuring that this operator is of weak or strong type from [Formula: see text] into [Formula...

Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity. Amyloid but not soluble forms of these peptides enhance HIV infection. Thus, agents that remodel these amyloid fibrils could prevent HIV transmission. Here, we confirm that the green tea polyphenol, epigall...

Address correspondence to: 12 13 Paul W. Hruz, 14 Washington University School of Medicine, 15 660 S. Euclid Ave., Campus Box 8208, 16 St. Louis, MO 63110. 17 Tel.: 314-286-2797; Fax: 314-286-2892; E-mail: [email protected] . 18 19 Christian Callebaut, 20 Gilead Sciences, 21 333 Lakeside Dr., 22 Foster City, CA 94404. 23 Tel: 650-522-6362 Fax: 650-522-5143; Email: christian.callebaut@gilead...