Myelodysplastic syndromes (MDS) are triggered by an aberrant hematopoietic stem cell (HSC). It is, however, unclear how this clone interferes with physiologic blood formation. In this study, we followed the hypothesis that the MDS clone impinges on feedback signals for self-renewal and differentiation and thereby suppresses normal hematopoiesis. Based on the theory that the MDS clone affects fe...

Myelodysplastic syndrome (MDS) is a slowly progressing hematologic malignancy associated with a poor outcome. Despite the relatively high incidence of MDS in the elderly, differentiation of MDS from de novo acute myeloid leukemia (AML) still remains problematic. Identification of genes expressed in an MDS-specific manner would allow the molecular diagnosis of MDS. Toward this goal, AC133 surfac...

Myelodysplastic syndromes (MDS) are a group of clonal disorders arising from hematopoietic stem cells generally characterized by inefficient hematopoiesis, dysplasia in one or more myeloid cell lineages, and variable degrees of cytopenias. Most MDS patients are diagnosed in their late 60s to early 70s. The estimated incidence of MDS in the United States and in Europe are 4.3 and 1.8 per 100,000...

Autoimmune manifestations (AIMs) are common in patients with myelodysplastic syndrome (MDS). This study aimed to investigate whether AIMs are associated with a specific cytogenetic abnormalities and worse survival in patients with MDS. A total of 67 MDS patients with AIMs and 134 age- and sex-matched MDS patients without AIMs, all of whom received medical care at Seoul National University Hospi...

Genetic lesions affecting epigenetic regulators are frequent in myelodysplastic syndromes (MDS). Polycomb proteins are key epigenetic regulators of differentiation and stemness that act as two multimeric complexes termed polycomb repressive complexes 1 and 2, PRC1 and PRC2, respectively. While components and regulators of PRC2 such as ASXL1 and EZH2 are frequently mutated in MDS and AML, little...

background orthopedic injuries are the most common types of injuries. to identify the main causes of injuries, collecting data in a standard manner at the national level are needed, which justifies necessity of making a minimum data set (mds). objectives the aim of this study was to develop an mds of the information management system for orthopedic injuries in iran. materials and methods this d...

(3%) and MPL (3%). Interestingly, it has been hypothesized that MDS with ring sideroblasts (MDS-RS) can transform into MDS/MPN-RS-T with acquisition of the JAK-2 mutation. Poor prognostic factors in MDS/MPN-RS-T include older age (>80), low Hb (<8 g/dl), abnormal cytogenetics, the presence of SETBP-1 or ASXL-1 mutations and the absence of SF3B1 or JAK-2 mutations. It is interesting to compare o...

Mobile Data Services (MDS) are increasingly important as revenues from voice calling are decreasing for mobile carriers, and there are many predictions that the use of MDS will increase in Australia. To explore the characteristics of MDS users, we conducted a survey with over 6000 respondents in Australia. The findings show that age is the most important demographic variable which influences th...

Multidimensional scaling (MDS) is a generic name for a family of algorithms that construct a configuration of points in a target metric space from information about inter-point distances measured in some other metric space. Large-scale MDS problems often occur in data analysis, representation and visualization. Solving such problems efficiently is of key importance in many applications. In this...

Maximal distance separable (MDS) matrices are important components for block ciphers. In this paper, we present an algorithm for searching 4 × 4 MDS matrices over GL(4, F2). By this algorithm, we find all the lightest MDS matrices have only 10 XOR counts. Besides, all these lightest MDS matrices are classified to 3 types, and some necessary and sufficient conditions are presented for them as we...