نتایج جستجو برای: لیپوکالین 2 lcn2
تعداد نتایج: 2525477 فیلتر نتایج به سال:
PURPOSE Lipocalin-2 (Lcn2) has been recognized as an adipocyte-derived acute phase protein that is positively correlated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. The effects of resistance and endurance training (RT vs. ET) on plasma lipocalin-2 are still unclear. Therefore, the purpose of this study was to examine the effects of RT vs. ET on plasma lipocali...
Iron overload damages many organs. Unfortunately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes. Here we show that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resulting in urinary excretion. Because K3Cys maintains recognition of its cognate ligand, the iron sider...
Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators. In innate immunity, siderocalin slows the growth of infecting bacteria by sequestering bacterial ferric siderophores. Siderocalin also binds simple catechols, which can serve as siderophores in the damaged urinary tract. Siderocalin has ...
Objetivo: relatar a atuação fisioterapêutica na lipofuscinose ceróide neuronal tipo 2 infantil tardia. Metodologia: relato de experiência, prospectivo, longitudinal caráter qualitativo, desenvolvido partir da vivência prática do estágio supervisionado obrigatório em Fisioterapia Neurofuncional, quinto ano curso Universidade Estado Pará (UEPA) realizado Unidade Ensino e Assistência Terapia Ocupa...
PURPOSE Mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8) mimic features of human Stargardt disease and age-related macular degeneration. RNA-sequencing of whole eyes was done to study early gene expression changes in Abca4-/-Rdh8-/- mice. METHODS Abca4-/-Rdh8-/- mice at 4 weeks of age were exposed to intense light. Total RNA was extracted from whole e...
Due to the heterogeneous nature of breast cancer, metastasis organotropism has been poorly understood. This study assessed specific cancer-related gene expression changes occurring with metastatic cancer recurrence distant organs compared non-metastatic cancer. We found that several secreted mediators encoding genes notably, LCN2 and S100A8 overexpressed at site spine (LCN2, 5-fold; S100A8, 6-f...
لیپوکالین ـ2، آدیپوکاین جدیدی است که از بافت چربی ترشح می‌شود و با التهاب خفیف، چاقی، مقاومت انسولینی و سندروم متابولیک ارتباط نزدیکی دارد. هدف پژوهش حاضر، بررسی تأثیر 8 هفته تمرین منتخب در آب بر سطوح لیپوکالین ـ2، شاخص‌های گلیسمیک و پروفایل لیپیدی در مردان میانسال دارای اضافه‌وزن بود. بدین‌منظور 24 مرد دارای اضافه وزن (Kg/m225BMI≥) 45 تا 55 ساله به‌صورت فراخوان عمومی، از میان 70 دا...
Submit Manuscript | http://medcraveonline.com Abbreviations: BSA: Bovine Serum Albumin; CD4: Cluster of Differentiation 4; CPS: Capsular Polysaccharide; CXCL10: Chemokine X Chemotactic Ligand 10; DHBA: Dihydroxybenzoic Acid; ER Stress: Endoplasmic Reticulum Stress; FBS: Fetal Bovine Serum; HLA: Human Leukocyte Antigen; IP-10: InterferonInducible Protein 10; LCN2: Lipocalin 2; NGAL: NeutrophilGe...
IroB is a C-glycosyltransferase encoded in the iroA cluster. C-Glucosylation of the bacterial siderophore enterobactin by IroB is a strategy some pathogenic bacteria use to evade the host's innate immunity mediated by lipocalin 2 (Lcn2). Without this modification, enterobactin can be tightly bound by host Lcn2, rendering it ineffective as a siderophore. Therefore, IroB inhibitors could be poten...
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