سندرم overlap به مواردی گفته میشود که تظاهرات چند بیماری بافت همبند را دریک بیمار مشاهده کنیم که یکی از تظاهرات آن درگیری ریوی به صورت آلوئولیت می باشد . مورد گزارش شده خانم 34 ساله ای بود که هفت سال پیش با تشخیص آرتریت روماتوئید تحت درمان بوده است واکنون با تنگی نفس کوششی و تظاهرات بیماریهای همبند همچون لوپوس سیستمیک، اسکلرودرمی ودرماتومیوزیت مراجعه نموده، در hrct به عمل آمده از بیمار تصویرgro...

Discoid lupus erythematosus is known as a rare disease in children manifesting itself with erythematose scaly plaque in area exposed to sunlight. In case of extensive disease, it could progress toward SLE. In this study, we report a case of a 5 year-old boy, residing in Tabriz, who had erythematose and atrophic scaly lesions on scalp, face, and fingers. Pathologic studies showed typical changes...

    The patient was a nine-year-old girl with prolonged focal seizure admitted to the pediatric ward of Rasoul-e-Akram Hospital. The child seemed to be depressed, and in physical examination the only abnormal finding was pink discoid rashes on the cheeks. Brain Ct-Scan performed at the emergency department yielded no specific findings. In order to investigate the precise cause of focal seizure,...

Background: Systemic Lupus Erythematosus (SLE) is a prototypic autoimmune disease with diverse clinical manifestations in association with autoantibodies to components of the cell nucleus. SLE as a chronic autoimmune disease has a worldwide distribution. There is a wide variation in the natural history of SLE among different ethnic and geographic groups. Our SLE registry is one of the largest s...

    Background & Objective: Recent accumulated evidence suggests that prolactin is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus(SLE). Stimulating immune system, this peptide hormone increases the severity of SLE. The purpose of our study was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation w...

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, involves almost all organs such as skin, heart, kidneys and central nervous system. The disease is characterized by vascular and connective tissue inflammation in a recurring pattern of remission and flare. Although the exact pathophysiology of disease has not been fully understood yet, the fundamental defect in SLE is attribut...

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