ment of acquired, refractory and fatal diseases in addition to inheritable gene deficiency diseases. Moreover, its application range is spreading to acute diseases or traumas. The gene delivery systems in vivo can be categorized as viral and nonviral approaches. Safety in usage of viral vectors for clinical gene therapy is not yet sufficient, whereas plasmid DNA (pDNA), which is a typical nonvi...

Background Recent studies suggest plasma neurofilament light (p-NFL) and phosporylated-Tau-181 (p-pTau181) are valuable biomarkers for detecting faster cognitive decline in patients with Alzheimer’s Disease (AD) dementia. Recently, AD subtyping has been used to subgroup into phenotypes possibly different prognoses. The aim of this study was investigate the interaction between p-NFL p-pTau-181 s...

Proliferating hepatic stellate cells (HSCs) respond to liver damage by secreting collagens that form fibrous scar tissue, which can lead to cirrhosis if in appropriately regulated. Advancement of microRNA (miRNA) hepatic therapies has been hampered by difficulties in delivering miRNA to damaged tissue. However, exosomes secreted by adipose-derived mesenchymal stem cells (ADSCs) can be exploited...

The relationship between neuronal alpha-bungarotoxin binding proteins (alpha BGTBPs) and nicotinic acetylcholine receptor function in the brain of higher vertebrates has remained controversial for over a decade. Recently, the cDNAs for two homologous putative ligand binding subunits, designated alpha BGTBP alpha 1 and alpha BGTBP alpha 2, have been isolated on the basis of their homology to the...

Trametes cervina lignin peroxidase (LiP) is a unique enzyme lacking the catalytic tryptophan strictly conserved in all other LiPs and versatile peroxidases (more than 30 sequences available). Recombinant T. cervina LiP and site-directed variants were investigated by crystallographic, kinetic, and spectroscopic techniques. The crystal structure shows three substrate oxidation site candidates inv...

This essay looks at the historic significance of an APS classic paper (http://www.the-aps.org/publications/classics/) that is freely available online: Falk G. Maturation of renal function in infant rats. Am J Physiol 181: 157-170, 1955 (http://ajplegacy.physiology.org/cgi/reprint/181/1/157).