A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion. Coupled with in vitro studies on BPA metabolism in the liver and the small intestine, the PBPK model was parameterized using oral pharmacokinetic data...

For better understanding of conformational stability of the dipeptide model HCO—Gly—L—Leu—NH2,ab initio and DFT computations at HF/6-31G(4 6-311++G(d,p) and B3LYP/6-31G(d) levels oftheory were carried out. Geometry optimization of the dipeptide within the leucine (Leu) side chainangles (x2 ,x2) resulted in three stable conformations as followings: anti-anti, the most stable one,(Xi = 180°, x2 =...

the nmr spectra of azo dyes, 5-arylazobarbituric (5a-g), 5-arylazo-1,3-dimethylbarbituric(6a-g) and 5-arylazothiobarbituric acids (7a-g) were studied in dmso-d6 in differentconcentrations. an intramolecular hydrogen bond was observed and indicating that thehydrazone forms is mostly predominant. the peak of the hydrazone proton was severelybroadened and its chemical shift appeared at down field ...

Following an eight-dimensional gauged supergravity approach we construct the most general solution describing D6-branes wrapped on a Kähler four-cycle taken to be the product of two spheres of different radii. Our solution interpolates between a Calabi–Yau four-fold and the spaces S × S × S × IR or S × S × IR, depending on generic choices for the parameters. Then we turn on a background four-fo...

This documents states the research agenda for the future of cryptology. We show which areas deserve more research bridging the gap between applications and research. For more detailed problems see the STORK document “D6 – Open Problems in Cryptology”.

Full and unambiguous asssignment of all Hand C-NMR resonances of the free bases as well as the hydrochloride salts of the antiarrhythmic agent propafenone and a thiophene analogue in different solutions (DMSO-d6, CDCl3) is reported.

Abstract Study question Are there cell lineage-related differences in the apoptotic rates of human blastocysts classified as euploid, mosaic and aneuploid after preimplantation genetic testing for aneuploidy (PGT-A)? Summary answer In blastocysts, apoptosis is more frequent trophectoderm (TE) cells associated with presence uniform chromosomal alterations. What known already Embryos diagnosed PG...

Abstract Study question Is there any benefit of extending culture until day (D) 7 to increase euploid blastocysts yield and clinical outcomes in a PGT-Aneuploidy analysis (PGT-A) program? Summary answer Extended D7 increases cumulative live birth. Highest was observed patients aged ≤41 with ≤2 D5/D6 biopsied. What is known already It well-known that female age the strongest predictive factor em...

PURPOSE Chemokines may play vital roles in breast cancer progression and metastasis. The primary members of chemokine decoy receptors (CDR), DARC and D6, are expressed in breast tumors and lymphatic/hematogenous vessels. CDRs sequestrate the pro-malignant chemokines. We hypothesized that breast cancer patients carrying different levels of CDR expression in tumor and/or in host might have differ...

The decrease in insulin sensitivity (IS) during myocardial infarction (MI) is recognized as a possible contributor to poor patient outcomes. Despite its potential relevance, a standardized and convenient IS assessment tool has yet to be established for said clinical scenarios. This study aimed to validate the accuracy of surrogate indexes in determining IS in acute MI patients by comparison wit...