نتایج جستجو برای: فنوباربیتال ویتامین d3

تعداد نتایج: 19910  

Journal: :Investigative ophthalmology & visual science 2014
Jawaher A Alsalem Deepali Patel Radhika Susarla Miguel Coca-Prados Rosemary Bland Elizabeth A Walker Saaeha Rauz Graham R Wallace

PURPOSE Vitamin D3 is a secosteroid mainly synthesized from the conversion of the skin precursor 7-dehydrocholesterol (7DHC) to vitamin D3 by ultraviolet (UV) B sunlight. Extrarenal synthesis of vitamin D3 has been reported in many tissues and cells, including barrier sites. This study characterizes the expression of components of vitamin D3 signaling in human ocular barrier cells. METHODS Pr...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Giancarlo Pruneri Lorenzo Pignataro Stefano Valentini Sonia Fabris Patrick Maisonneuve Nadia Carboni Salvatore Pece Maria Capra Barbara Del Curto Antonino Neri Giuseppe Viale

PURPOSE To analyze the prevalence and clinical relevance of cyclin D3 abnormalities in laryngeal squamous cell carcinoma (LSCC). EXPERIMENTAL DESIGN Cyclin D3 immunoreactivity was evaluated in 223 formalin-fixed and paraffin-embedded samples of LSCC patients with a mean follow-up of 62.8 +/- 43.2 months. The occurrence of cyclin D3 extra signals was analyzed by fluorescence in situ hybridizat...

قضاوی, علی, مسیبی, قاسم, پایانی, محمدعلی,

    Background & Aim: Multiple sclerosis(MS) is a chronic autoimmune disease of unknown etiology affecting the central nervous system. The prevalence of MS is the highest where environmental supply of vitamin D is low. Some studies have shown a strong protective effect of vitamin D3 on experimental autoimmune encephalomyelitis(EAE) of MS model, but it is not known how it affects EAE. Vitamin D3...

ژورنال: :کومش 0
محمدطاهر بروشکی m. t. boroushaki dept of pharmacology, school of medicine, mashhad university of medical sciences, mashhad, iranدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، بخش فارماکولوژی فرهاد ملک f. malek dept of internal medicine, school of medicine, semnan university of medical sciences, semman, iranدانشگاه علوم پزشکی سمنان، دانشکده پزشکی، گروه طب داخلی ابوالقاسم بهارلو a. baharloo dept of pharmacology, school of medicine, mashhad university of medical sciences, mashhad, iranدانشگاه علوم پزشکی مشهد، دانشکده پزشکی، بخش فارماکولوژی

سابقه و هدف: با توجه به مزمن بودن بیماری های تشنجی و مصرف طولانی مدت داروهای ضد تنشج و همچنین عوارض فراوان این داروها، اخیرا استفاده از گیاهان دارویی جهت کنترل حملات تشنجی مورد توجه پژوهشگران قرار گرفته است. هدف این تحقیق، بررسی اثر ضد تشنجی عصاره گیاه آکلیل کوهی (rosmarinus officinalis) در کنترل تشنجات ناشی از پنتیلن تترازول در موش سفید آزمایشگاهی می باشد. مواد و روش ها: مقادیر متفاوتی از عصار...

2014
Y. D. Jang M. D. Lindemann H. J. Monegue R. L. Stuart

Four experiments were conducted to investigate the effect of fat-soluble vitamin administration to sows or newborn pigs on plasma vitamin status. In Exp. 1 and 2, a total of 24 and 43 newborn pigs were allotted to control and vitamin treatments (vitamin D3 with variable addition of vitamins A and E) orally or by i.m. injection. In Exp. 3, pigs from Exp. 2 were allotted to 2 treatments (±vitamin...

2017
Luis G Vargas Buonfiglio Marlene Cano Alejandro A Pezzulo Oriana G Vanegas Calderon Joseph Zabner Alicia K Gerke Alejandro P Comellas

INTRODUCTION Vitamin D3 supplementation has been reported to prevent lung infections and increase the gene expression of antimicrobial peptides such as cathelicidin. We investigated the effect of vitamin D3 supplementation on the antimicrobial activity of airway surface liquid (ASL) in human subjects. Since smoking can increase the risk of respiratory infections, we also investigated the effect...

2017
Muhammad M. Hammami Ahmed Yusuf

BACKGROUND Vitamin D (D) supplements are indispensable for its world-wide deficiency. Controversy continues on ergocalciferol (D2) and cholecalciferol (D3) relative potency as well as on dosing-schedule and sex role in raising 25-hydroxy D (25(OH)D) level, the best indicator of D status. METHODS We randomized 279 adults to daily D2, D3, D2/D3, or placebo; 2-weekly D2 or D3; or 4-weekly D2 or ...

Journal: :Cancer research 1994
M Shabahang R R Buras F Davoodi L M Schumaker R J Nauta M R Uskokovic R V Brenner S R Evans

The use of 1,25-dihydroxyvitamin D3 as an antiproliferative agent in the treatment of cancer is limited by its hypercalcemic effects. Analogues with equivalent or greater antiproliferative activities but smaller hypercalcemic effects have been developed. The antiproliferative effects of 1,25-dihydroxyvitamin D3 and four analogues were studied in HT-29 and SW620 human colon cancer cell lines, mo...

2013
Wipawee Winuthayanon Pawinee Piyachaturawat Apichart Suksamrarn Katherine A. Burns Yukitomo Arao Sylvia C. Hewitt Lars C. Pedersen Kenneth S. Korach

BACKGROUND Diarylheptanoid (D3) isolated from the medicinal plant, Curcuma comosa, has estrogenic activity. OBJECTIVE We aimed to elucidate the mechanism(s) of D3 action and compare it with that of 17β-estradiol (E2) using both in vitro and in vivo uterine models. METHODS We used human uterine (Ishikawa) cells to determine the estrogenic action of D3 on the activation and nuclear translocat...

2000
Pamela A. Hershberger Ruth A. Modzelewski Zoya R. Shurin Robert M. Rueger Donald L. Trump Candace S. Johnson

1,25-Dihydroxycholecalciferol (1,25-D3) has significant antitumor effects in the murine squamous cell carcinoma (SCC) tumor model in vitro and in vivo. We investigated the basis for this antiproliferative activity and found that, in vitro, 1,25-D3 administration is associated with altered expression of cell cycle regulatory proteins, treatment results in retinoblastoma dephosphorylation, decrea...

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