The analysis of gene regulatory networks has become one of the most challenging problems of the postgenomic era. Earlier we developed rSNP_Guide (http://util.bionet.nsc.ru/databases/rsnp.html), a computer system and database devoted to prediction of transcription factor (TF) binding sites (TF sites), which can be responsible for disease phenotypes. The prediction results were confirmed by 70 kn...

Tissue factor (TF) is the major initiator of blood coagulation, and a mediator of inflammation, angiogenesis, and carcinogenesis. According to recent evidence, preformed TF and inducible expression of the protein is observed in several blood components. TF is apparently constitutively expressed on circulating microparticles, and can be exposed within minutes on the cell membrane of activated eo...

Existence of a close relationship between increased clotting and malignancy has been clearly recognized for over a century. Many tumor cell types express tissue factor (TF), a procoagulant protein, on their cell surfaces. Tissue factor is a transmembrane cellular receptor for coagulation factor VII/VIIa. Binding of factor VIIa to TF triggers the activation of coagulation cascade leading ultimat...

This issue of Arteriosclerosis, Thrombosis, and Vascular Biology contains 4 reviews on tissue factor (TF) and 1 on tissue factor pathway inhibitor (TFPI). One review on TF will be published in a later issue. In this editorial, we will briefly revisit the major advances in the field, highlight some of the current controversies, and discuss some of the future challenges. TF (also known as tissue ...

in the turfgrass industry, the need for salinity tolerant turfgrasses is increasing because of the increased use of saline and non-potable water. greenhouse container experiments were conducted to determine the relative salinity tolerance and growth responses of eleven native populations of tall fescue (festuca arundinacea schrub) (tf), including: semirom, mashhad, sanandaj, yasuj, yazd abad, d...

In the turfgrass industry, the need for salinity tolerant turfgrasses is increasing because of the increased use of saline and non-potable water. Greenhouse container experiments were conducted to determine the relative salinity tolerance and growth responses of eleven native populations of tall fescue (Festuca arundinacea Schrub) (TF), including: Semirom, Mashhad, Sanandaj, Yasuj, Yazd Abad, D...

Cancer patients often have an activated clotting system and are at increased risk for venous thrombosis. In the present study, we analyzed tissue factor (TF) expression in 4 different human pancreatic tumor cell lines for the purpose of producing derivative tumors in vivo. We found that 2 of the lines expressed TF and released TF-positive microparticles (MPs) into the culture medium. The majori...

Tissue factor (TF) is an integral membrane glycoprotein which, as the receptor and essential cofactor for coagulation factors VII and VIIa (FVII and FVIIa, respectively), is the primary cellular activator of the coagulation protease cascade. Previous studies on the procoagulant activity of a variety of cell types (either lysed or in the intact state) have variously been interpreted as showing t...

An expression construct harboring granulocyte colony-stimulating factor (G-CSF)-transferrin (Tf) fusion protein (G-CSF-Tf) was engineered by fusing human cDNAs encoding G-CSF and Tf to explore the feasibility of using Tf as a carrier moiety for oral delivery of therapeutic proteins. The recombinant protein, G-CSF-Tf, was harvested from protein-free, conditioned medium of transfected HEK293 cell...

We present a detailed analysis, based on the forward flux sampling simulation method, of the switching dynamics and stability of two models of genetic toggle switches, consisting of two mutually repressing genes encoding transcription factors (TFs); in one model (the exclusive switch), the two transcription factors mutually exclude each other's binding, while in the other model (general switch)...