The aerial parts of H. perforatum subsp. perforatum and H. perforatum subsp. angustifolium were investigated for their chemical composition and antimicrobial activity. Spectrophotometric analysis indicated that H. perforatum subsp. perforatum is richer in flavonoids and tannins than the other subspecies. HPLC analysis confirmed the higher yield of flavonoids in H. perforatum subsp. perforatum a...

AIM Effects of homeopathic treatment with Hypericum perforatum (Hypericum) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. METHODS Fifty-four male healthy White Wistar rats were divided into three experimental groups (n = 18), randomly: Sham-operation (Sham), control: silicon tube (Sil) and treatment: silicon tube + Hypericum (Sil/Hypericum). In the S...

The extent of phenotypic variation of St. John's wort (Hypericum perforatum L.) plants transformed with wild agropine ATCC 15834 Agrobacterium rhizogenes plasmid was evaluated with respect to the number of rol genes integrations. The transfer of T(L)-DNA to plant explants during each transformation event was incomplete with different rolA, rolB, and rolC copy numbers. Along with typical feature...

CHAIRMEN AND MATHEMATICS (A) PHYSICS (B) CHEMISTRY (C) ASTRONOMY (D) Lipman Bers Edwin M. McMillan Thomas E. Taylor Frank D. Drake SECRETARIES OF F. A. Ficken Rolf M. Sinclair Leo Schubert Arlo U. Landolt AAAS SECTIONS PSYCHOLOGY (J) SOCIAL AND ECONOMIC SCIENCES (K) HISTORY AND PHILOSOPHY OF SCIENCE Carl P. Duncan Robert K. Merton Ernest Nagel William D. Garvey Harvey SapoIsky Dudley Shapere IN...

Hypericum perforatum L. (St. John’s wort) is a well-known medicinal plant that possesses secondary metabolites with beneficial pharmacological properties. However, improvement in the production of via genetic manipulation challenging task as H. remains recalcitrant to Agrobacterium tumefaciens-mediated transformation. Here, transcripts key genes involved several defence responses (secondary met...

OBJECTIVE To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats. METHODS Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to dia...

Hypericum perforatum (St John's wort) is a reservoir of diverse classes of biologically active and high value secondary metabolites, which captured the interest of both researchers and the pharmaceutical industry alike. Several studies and clinical trials have shown that H. perforatum extracts possess an astounding array of pharmacological properties. These properties include antidepressant, an...