Dear Sir, I read with interest a recent article by Antonodimitrakis and colleagues in your journal presenting a case of acquired hemophagocytic lymphohistiocytosis (HLH) in a 60-year-old woman suffering from diabetes mellitus type 2 (1). The reported patient developed a life-threatening HLH associated with a reactivation of an Epstein–Barr virus (EBV) infection and was successfully treated by m...

BBA68 (BbCRASP-1) of the Lyme disease spirochetes binds human factor H (FH) and FH-like protein 1 (FHL-1). Here we assess transcription of the BBA68 gene and production of BBA68 in infected mice and humans using real-time reverse transcriptase PCR and immunoblotting. The species specificity of FH binding to BBA68 was also tested. The data suggest that BBA68 does not play an important role in im...

Perforin gene (PRF1) mutations have been reported in 20-30% of patients with familial hemophagocytic lymphohistiocytosis (FHL), an immune disorder of infancy and early childhood. Cytotoxic T and natural killer (NK) cell activities are remarkably reduced or ab-sent in FHL patients. We report the first cases of familial hemophagocytic lymphohistiocy-tosis in an Iranian family with two siblings. E...

sphingosine-1-phosphate (s1p) is a bioactive platelet-derived sphingolipid involved in regulation, proliferation, differentiation, hypertrophy and anti-apoptosis of cells and activation of satellite cells. the aim of the present study was to investigate s1p as a growth factor in response to resistance training in male wistar rats. 24 eight-week-old male wistar rats (190–250 gr.) were used in th...

1 Department of Animal Science, Faculty of Science and Technology, Aarhus University, P.O. Box 50, 8830 Tjele, Denmark; E-Mails: [email protected] (H.N.L.); [email protected] (K.E.B.K.) 2 Department of Food Science, Faculty of Life Science, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark; E-Mail: [email protected] 3 Novozymes A/S, Krogshøjvej 36, DK-2...

Reconstruction following excision of tumors of the Achilles tendon poses a challenge to the treating surgeon. Described techniques for restoration of plantarflexion in the setting of an unrepairable tendon include the use allograft, autograft, tendon transfer, and free flap. In tumor surgery, options may be limited as total tendon resection may be necessary leaving little or no residual tendon ...

Yoshida N, Tsuchida Y. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222231 Description A 37-year-old man presented to the emergency department with right lower limb pain after being hit by an excavator. His right ankle was swollen, but no open wounds were observed. Radiography and CT of the right ankle revealed a medial malleolus ankle fracture (figure 1A,B). During his treatment with osteosynthesis...

Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix. One 52-kDa protein was eluted and identified by mass spectrometry as glycerol-3-phosphate dehydrogenase 2 (Gpd2). Consequently, Gpd2 was rec...