Platelet factor 4 (PF-4) inhibits angiogenesis in vitro and in vivo. The mechanism of inhibition is poorly understood. We have investigated the mechanism of inhibition by examining the interaction of PF-4 and the fibroblast growth factor-2 (FGF-2)/fibroblast growth factor receptor (FGFR) system. PF-4 inhibited the binding of FGF-2 to high-affinity and low-affinity binding sites in murine microv...

There is evidence suggesting that herbal extracts demonstrate greater bioactivities than their isolated constituents at an equivalent dose. This phenomenon could be attributed to the absence of interacting substances present in the extracts. By measuring the pharmacokinetic parameters of paeoniflorin (PF) and albiflorin (AF) after being orally administered to rats in isolated form, in combinati...

UNLABELLED The aim of this study was to evaluate the role of radioimmunoscintigraphy (RIS) directed against prostate-specific membrane antigen (PSMA) in influencing postradical retropubic prostatectomy (RRP) radiotherapy (RT) decision making. METHODS The records of consecutive patients who underwent RRP, who were referred for consideration of RT, and for whom an RIS scan was obtained were rev...

A dinuclear cobalt capsule [PF(6) subset(CH(3)CN)(2)(Co(2)L(4))][PF(6)](3) (2), (L = bis-benzimidazole-1,3-phenylene) has been prepared using a self-assembly approach. This unique class of cage is perfectly designed to encapsulate weakly coordinated anions, i.e. BF(4)(-) and PF(6)(-)via an Manion weak interaction as illustrated by X-ray and solid-state NMR investigations. Selective anion bindin...

Introduction: Binging is the consumption of larger amounts of food in a briefer period of time than would normally be consumed under similar circumstances. Binging requires palatable food (PF) to trigger abnormal eating, probably reflecting gene × environment interactions. In this study we examined the impact of trait binge eating (BE) and its compulsive nature on the conflict between hedonic e...

Stem and pod rot of groundnut is an economically important soil borne disease caused by Sclerotium rolfsii Sacc. The present study aimed to evaluate the indigenous bacterial bio control agent Pseudomonas fluorescens strains having multiple traits related plant growth promoting activity. Healthy rhizospheric from field was collected different North Karnataka districts. Nineteen P. were isolated ...

كان لسياسة النظام البعثي في ​​العراق أثر كبير ظهور وتوسع الأحزاب والحركات المعارضة للنظام ، خاصة بعد الغزو العراقي للكويت وقيام الانتفاضة الشعبانية والأساليب القمعية التي مارسها مع الشعب المعارض. كانت ضعيفة داخليا ولم تكن موحدة بل هناك اتجاهات مختلفة مما أضعف موقفها الداخل، وعلى الصعيد الدولي فضلا عن رفض لأي شكل من أشكال المعارضة، لذلك عامل الاحزاب بقسوة ووحشية، اضعفها بشكل كبير، ناهيك تدخل دور...

We consider that the outer hair cells of the inner ear together with the local structures of the basilar membrane, reticular lamina and tectorial membrane form the primary filters (PF) of the second order. Taking into account a delay in transmission of the excitation signal in the cochlea and the influence of the Reissner membrane, we design a signal filtering system consisting of the PF with t...

Associative learning is important on rapid timescales, but no suitable form of short-term plasticity has been identified that is both associative and synapse specific. Here, we assess whether endocannabinoids can mediate such plasticity. In the cerebellum, bursts of parallel fiber (PF) activity evoke endocannabinoid release from Purkinje cell dendrites that results in retrograde synaptic inhibi...