Activation of protein kinase C (PKC) and the resulting phosphorylations of proteins in vivo were examined in mouse epidermis, a target tissue of tumor-promoting phorbol diesters, such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Treatment of mouse skin with TPA caused rapid translocation of PKC from the cytosol to the membrane fraction of skin tissue, followed by its down regulation. Epiderm...

PURPOSE Studies of myopia in mice have been complicated by the difficulty in obtaining accurate measurements of small changes observed in the growing mouse eye in vivo and the lack of data on refractive eye development. The purpose of this study was to carry out an in vivo high-resolution analysis of mouse eye growth and refractive development. METHODS High-resolution small animal magnetic re...

OBJECTIVES The aim of this study was to evaluate serum interleukin (IL) 12 concentration in patients with juvenile chronic arthritis (JCA), according to disease subtype, activity, and duration. IL12 has been demonstrated to prime the selective expansion of T helper (Th) cells with a Th1-type pattern of cytokine production. METHODS Sixty eight serum samples from 50 JCA patients (12 systemic, 1...

The recent identification of tumor Ags as potential vaccines has prompted the search for efficient adjuvants and delivery systems, especially in the case of peptide-based vaccination protocols. Here, we investigated the adjuvant potential of the recombinant 40-kDa outer membrane protein of Klebsiella pneumoniae (P40) for specific CTL induction. We studied the CTL response induced in HLA-A*0201/...

Aloe vera (AV) süt, dondurma, şekerleme, sağlık içecekler gibi fonksiyonel gıdalarda kullanılmaktadır. Yapılan bu araştırmada, yoğurt kültürüne probiyotik ve teknolojik özelliklere sahip olan Lactobacillus plantarum AB6-25 suşu, %1, 2,5 5 oranlarında AV jel içeceği ilave edilerek üretimi yapılmıştır. Depolamanın 1, 7, 14 21. günlerinde üretilen yoğurtların fizikokimyasal, mikrobiyolojik analizl...

JEL Classification Code(s): J 31, J 71) "Perceptions of Discrimination, Effort to Obtain Psychological Balance, and Relative Wages: Can We Infer a Happiness Gradient?" There is a substantial literature that finds a linkage between happiness and relative economic well being as measured by earnings or wages. There is also a well documented racial gap in wages. One explanation for this is disparat...

Lactobacillus delbrueckii UFV-H2b20 has been shown to increase clearance of bacteria injected into the blood of germ-free mice. Moreover, it induces the production of type 1 cytokines by human peripheral mononuclear cells. The objective of the present study was to investigate the production of inflammatory cytokines [interleukin-12 (IL-12 p40), tumor necrosis factor-alpha (TNF-alpha), and inter...