Recent studies suggested that lactate accumulation can be a signal for mitochondrial biogenesis in skeletal muscle. We investigated whether reductions in lactate concentrations in response to dichloroacetate (DCA), an activator of pyruvate dehydrogenase, attenuate mitochondrial adaptations after exercise training in mice. We first confirmed that DCA administration (200 mg/kg BW by i.p. injectio...

BACKGROUND C9, a newly in silico-designed inhibitor of microtubule dynamics induces G2/M arrest culminating in apoptosis. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase, an enzyme that promotes pyruvate entry into mitochondria. The use of antitumor drugs targeting different cancer features can be a more effective way to overcome drug resistance. METHODS The influence of C9 (130 ...

The Dendritic Cell algorithm (DCA) is inspired by recent work in innate immunity. In this paper a formal description of the DCA is given. The DCA is described in detail, and its use as an anomaly detector is illustrated within the context of computer security. A port scan detection task is performed to substantiate the influence of signal selection on the behaviour of the algorithm. Experimenta...

A novel hybrid structure of bimetallic dicyanamide decorated BiVO4 is developed via a simple method to accelerate interfacial water oxidation kinetics. Two types dicyanamides, CoNi(dca)2 and CoFe(dca)2, are coated on photoanodes found exhibit far more enhanced PEC performance than Co(dca)2 or Ni(dca)2 as cocatalysts. The successful deposition metal dicyanamides confirmed by physical characteriz...

Dichloroacetic acid (DCA) is carcinogenic to the B6C3F(1) mouse and the F344 rat. Given the carcinogenic potential of DCA in rodent liver and the known concentrations of this compound in drinking water, reliable biologically based models to reduce the uncertainty of risk assessment for human exposure to DCA are needed. Development of such models requires identification and quantification of pre...

INTRODUCTION Due to the inadequate response to inhaled corticoids, patients with difficult-to-control asthma (DCA) are submitted to oral corticoids or use of Omalizumab. Although it is necessary to treat these patients, a significant relationship between steroid usage and both peripheral and respiratory weakness muscle, results in implications such as loss of quality of life and compromised lun...

BACKGROUND 3-bromopyruvate (3-BrPA) and dichloroacetate (DCA) are inhibitors of cancer-cell specific aerobic glycolysis. Their application in glioma is limited by 3-BrPA's inability to cross the blood-brain-barrier and DCA's dose-limiting toxicity. The safety and efficacy of intracranial delivery of these compounds were assessed. METHODS Cytotoxicity of 3-BrPA and DCA were analyzed in U87, 9L...

A medium access control (MAC) protocol for spread-spectrum ad hoc networks with dynamic channel allocation (DCA) is presented. DCA can support large systems with a smaller number of channels by dynamically assigning channels only when a node has a packet to transmit. The protocol extends cross layer, with the scheduling at the MAC, and assignment of channels at the physical layer by means of a ...

We introduce dynamic communicating automata (DCA), an extension of communicating finite-state machines that allows for dynamic creation of processes. Their behavior can be described as sets of message sequence charts (MSCs). We consider the realizability problem for DCA: given a dynamic MSC grammar (a high-level MSC specification), is there a DCA defining the same set of MSCs? We show that this...

Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the pyruvate dehydrogenase kinase, DCA reactivates the mitochondrial function and decreases the glycolytic flux in tumo...