Vimalanand S. Prabhu, Oliver A. Cornely, Yoav Golan, Erik R. Dubberke, Sebastian M. Heimann, Mary E. Hanson, Jane Liao, Alison Pedley, Mary Beth Dorr, and Stephen Marcella Economic and Data Sciences, Center for Real World and Observational Studies, Merck & Co., Inc., Kenilworth, New Jersey; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Department of Inter...

If you have been following current news in the pharmaceutical industry, you have likely heard about over 3500 product liability lawsuits that were filed against Merck in the past several years asserting claims arising from the use of the NuvaRing, an intravaginal contraceptive ring that releases ethinyl estradiol and etonogestrel. These claims alleged that the manufacturers failed to design and...

Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the second most common cause of death from cancer among women worldwide. This Review examines prophylactic HPV subunit vaccines based on the ability of the viral L1 capsid protein to form virus-like particles (VLPs) that induce high levels of neutralizing antibodies. Following preclinical research by laboratorie...

Dr Thase reports that during the past 2 years he has been a consultant or advisory board member for Adolar, Astra­ Zeneca, Bristol­Myers Squibb Company, Dey Pharma, Eli Lilly and Company, Forest Laboratories, GlaxoSmithKline, Janssen (Johnson and Johnson), MedAvante, Inc, Merck (for­ merly Schering­Plough), Neuronetics, Novartis, Otsuka, Pam­ Lab, Pfizer (formerly Wyeth Pharmaceuticals), Shire ...

1 Autophagosome formation during varicella-zoster virus infection following endoplasmic 2 reticulum stress and the unfolded protein response. 3 John E. Carpenter 1 , Wallen Jackson 1 , Luca Benetti 2 and Charles Grose 1 4 1. Children’s Hospital, University of Iowa, Iowa City, IA 5 2. Vaccine Manufacturing Sciences and Commercialization, Merck Manufacturing Division, 6 Merck, Sharp & Dohme Corp....

H and C NMR spectra were recorded with Bruker DPX-400, AVANCE-400 and DRX-500. The numbering of the protons relate to the numbering chosen in Fig. 1. High resolution mass spectra were obtained with a Micromass LCT via loop-mode injection from a Waters (Alliance 2695) HPLC system. Alternatively a Micromass Q-TOF in combination with a Waters Aquity Ultraperformance LC system was employed. Ionizat...

The aim of this study was to evaluate histologically, three types of calcium sulfate - Merck (Brazil), Surgiplaster (Italy) and Capset (USA) - in surgically created defects on rabbit femurs. Twenty male New Zealand rabbits were used. Two surgical bone defects (5 mm diameter x 8 mm depth) were created on each distal epiphysis using a #3 Dentoflex trephine bur. Defects were filled with: group 1 -...

In the past 5 years, D. W. D. has received grant support from Astellas, Merck, Pfizer, F2G, OrthoBiotech, Indevus, Basilea, The Fungal Research Trust, The Wellcome Trust, The Moulton Trust, The Medical Research Council, The Chronic Granulomatous Disease Research Trust, The National Institute of Allergy and Infectious Diseases and The European Union. He has been an advisor/consultant to Basilea,...

We proposed a new method to determine the rate constant of biochemical oxidation of soil organic ma�ers that makes it possible to evaluate their stability by Spectroquant Merck BOD photometric tests; if smaller samplings are used and individual determinations are performed, it can replace the method of BOD vacuum measuring by an Oxi Top Control Merck system. The time and labour consumption of t...