Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a demand for developing new effective strategies with focusing on tumor cells and minimum side effects. Targeted cancer therapies and personalized medicine have been defined as ...

Molecular-targeted therapy against tyrosine kinase receptors (RTKs) plays an important role in gastric cancer (GC) treatment. Understanding the correlation between RTK coexpression could better guide clinical drug use. In the present study, the coexpression status of c-MET, fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their cli...

Traditionally structural response due to severe conditions has been measured using accelerometers. However it is a relative acceleration measurement. The displacement from acceleration measurement cannot be obtained directly by simply applying the laws of motion through double integration. GPS-RTK offers direct displacement measurements for dynamic monitoring, but it has its own limitations. Th...

Receptor tyrosine kinase (RTK) signaling plays an instructive role in cell fate decisions, whereas Notch signaling is often involved in restricting cellular competence for differentiation. Genetic interactions between these two evolutionarily conserved pathways have been extensively documented. The underlying molecular mechanisms, however, are not well understood. Here, we show that Yan, an Ets...

Unmanned aerial vehicles (UAVs) equipped with a global real-time kinematic navigation satellite system (GNSS RTK) could be state-of-the-art solution to measuring gaps in sugarcane fields and enable site-specific management. Recent studies recommend the use of UAVs map these gaps. However, low-accuracy GNSS provides incomplete or inaccurate photogrammetric reconstructions, which easily generate ...

Abstract Thanks to the development of real-time kinematic (RTK) algorithm and emerging Global Navigation Satellite System (GNSS), especially for Galileo BeiDou-3, reliable positioning accuracy medium long-baseline RTK became possible globally. Moreover, with GNSS receiver hardware, baseline length limitations due radio-based communications are removed thanks internet-based communication. In thi...

High-precision global navigation satellite system (GNSS) is a crucial geolocalization feature enabling wide range of applications, from mobile Internet-of-Things devices to autonomous drones and self-driving vehicles. Real-time kinematic (RTK) GNSS technology that attracting increased interest due the centimeter precision achievable when wireless communication present on devices. On other hand,...

Topografyanın engebeli ve ulaşılması zor olduğu alanlarda yersel ölçüm teknikleri ile yapmadaki güçlükler nedeniyle uzaktan algılama kullanımını bu tür durumlarda vazgeçilmez kılmaktadır. Gerçek zamanlı kinematik (Real Time Kinematic-RTK) tekniği konumsal verilerin doğruluğunda santimetre hassasiyetinde çalışmalar ortaya konulabilmektedir. Ancak topoğrafik yapısı, uydu bazlı konumlamaya uygun o...

As the modern navigation business evolves, demands for high-precision positioning in GNSS-challenged environments increase, and integrated system composed of Global Navigation Satellite System (GNSS)-based Real-Time Kinematic (RTK), inertial (INS), Light Detection Ranging (LiDAR), etc., is accepted as most feasible solution to issue. For prior-map-free situations, only sensor with a global fram...