OBJECTIVE/BACKGROUND Factors such as body size (weight and body mass index [BMI]), age, sex, and race might influence the clinical response to sumatriptan. We evaluated the impact of these covariates on the plasma concentration (Cp) profile of sumatriptan administered subcutaneously. METHODS We conducted three pharmacokinetic studies of subcutaneous sumatriptan in 98 healthy adults. Sumatript...

We present the near-Maximal Algorithm for Poisson-disk Sampling (nMAPS) to generate point distributions variable resolution Delaunay triangular and tetrahedral meshes in two three-dimensions, respectively. nMAPS consists of principal stages. In first stage, an initial distribution is produced using a cell-based rejection algorithm. second holes sample are detected efficient background grid fill...

We introduce an approach for the stochastic characterization of geometric and hydraulic parameters a three-dimensional (3D) discrete fracture network (DFN) estimating their uncertainty based on data from tomography experiments. The inversion relies Bayesian framework resulting posterior distribution is characterized by generating samples Markov chain Monte Carlo (MCMC) methods. method evaluated...

Constructing and operating a large underground facility for the geological disposal of high-level radioactive waste decades will cause changes in environment around facility. Since permeability heterogeneity fractured granite Japan are higher than those Europe, disturbance to groundwater due tunnel excavation is expected be complex. Therefore, modeling fracture characteristics important accurat...

Abstract Two modeling approaches are commonly utilized for simulating flow in fractured formations: the discrete fracture network (DFN) approach and stochastic continuum (SC) approach. Although DFN is most accurate, it has computational memory constraints. The SC ensures fast processing but results system over-homogenization. (FC) arises as an integrated technique that incorporates merits of bo...